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Pre-clinical Liver Immunology Lead

Spark Therapeutics
Philadelphia, Pennsylvania. Hybrid and remote options available for select opportunities.
Salary not provided
Closing date
Oct 1, 2022

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Life Sciences, Immunology
Organization Type
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Job Details

As a member of larger Immunology Team in the Translational Department, the Preclinical Immunology Lead is responsible for strategic planning, execution, and reporting of pre-clinical immunology studies; initiates and directs immunological initiatives to support all Spark therapeutic areas with the goal of increasing safety and efficacy of all therapeutics. Proposes novel strategies to modulate immune responses in the context of gene therapy;. Keeps abreast of scientific and technological innovations. Directs external collaborations with the support of a dedicated business development partner. Leads a group of Scientists and Research Associates to support in-house immunology studies. Oversees CRO management for outsourced preclinical activities; develops novel immune assays in support of the Spark pipeline. Responsible for ensuring that all studies are compliant to relevant SOP guidelines and aligned with regulatory agency expectations.

Job Function and Description

Assume responsibility for strategic planning, execution, and reporting of pre-clinical in vivo and in vitro immunology studies in compliance with the appropriate regulatory guidance documents

Oversee CRO management for outsourced preclinical activities

Develop novel immune assays in support of the Spark pipeline

Directs external collaborations with the support of a dedicated business development partner

Keep abreast of new scientific/technology development by participating in scientific meetings/seminars and through regular scientific review.

    Manage performance. Ensure every team member knows what is expected of them, what it takes to be successful, and how they are progressing. Provide team members with continuous and on-going performance feedback. Hold everyone accountable to achieve results while demonstrating the Spark Values. Help team members understand how their work contributes to the overall success of Spark by periodically reviewing individual objectives to ensure alignment to corporate and functional objectives, making adjustments if priorities have shifted. Develop team members. Help employees effectively assimilate to Spark and continually grow through challenging experiences so they can realize their full potential. Understand your employee’s goals, strengths and motivators. Partner with your employees to identify areas for development, conduct coaching conversations regularly and provide guidance on ways to develop through on the job experiential learning, social networks and development opportunities. Foster Spark’s Culture, Mission, Vision, and Values: Lead by example. Create an environment where team members thrive in our Culture by living our truths, always in compliance with applicable laws and regulations. Emphasize to employees that “how” they achieve performance objectives is just as important as “what” they accomplish.


  • Ph.D. in Immunology or related field required and at least 6 years of relevant post degree experience
  • Previous experience as a team leader is preferred
  • A strong background in immunology and AAV gene therapy is preferred


Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.

Nearest Major Market: Philadelphia

Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.

Learn more about Spark Therapeutics and view other openings.


At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
3737 Market Street
Suite 1300
United States
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