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Senior Research Associate In-vivo (Ocular)

Spark Therapeutics
Pipersville, Pennsylvania. Hybrid and remote options available for select opportunities.
Salary not provided
Closing date
Jun 8, 2022

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Health Sciences, Drug Development
Job Type
Research Scientist
Organization Type
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Job Details

Primary Duties

The Senior Research Associate will be responsible for overseeing and performing in vivo studies to support the ocular therapeutic area and all the therapeutic areas of the translational team.

  • Perform Ocular in vivo studies to support in support of Spark pipeline.
  • Perform Intravitreal/Subretinal injections, monitor animal health, collect blood samples, perform necropsies and record data for mouse studies, other species as needed.
  • Perform Electroretinography, OCT and OKR monitoring in rodents.
  • Maintain rodent breeding colonies.
  • Perform IV/IP/PO/SC injections in mice and rats.
  • General supplies and reagent ordering.
  • Interact with ocular scientists and provide constant feedback.
  • Work crossfunctionally with CNS, and liver teams and provide support to other R&D in vivo as needed.
  • Schedule and follow multiple concurrent studies according to the experimental design.
  • Interact with scientists of different therapeutic areas and provide constant feedback.


Perform Ocular in vivo experiments in laboratory animals according to applicable regulations; studies will utilize mice and also rats, rabbits and other species, as needed

Train and assist technical staff in the performance of in vivo experiments to support ocular and other therapeutic areas.

Responsible for all safety aspects and best practices, and employee training.

Ensure departmental goals and objectives are met and aligned to the broader organizational goals and objectives.

Prioritize and plan projects and workloads, manage resources and personnel scheduling. Write and review animal protocols for IACUC approval

Education and Experience Requirements

  • Bachelor’s degree/MS in relevant field required and 5+ years of hands on experience with rodents.
  • Advanced skills on handling, restraining, dosing and performing a variety of procedures on study animals required.
  • Ability to manage large mouse colonies required.
  • Excellent organizational, communication and collaborations skills.
  • Keep accurate records, follow instructions and comply with company policies.
  • Experience with AAV vectors is a plus.

Key Skills, Abilities, and Competencies

  • Strong organizational skills.
  • Excellent writing and verbal communication skills.
  • Proficiency

Complexity and Problem Solving

  • Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems; Discuss with supervisor and refer to policies/practices for guidance.
  • Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
  • Exercise judgment within defined procedures and practices to determine appropriate action.

Internal and External Contacts

Quality Assurance, Clinical Operations, Pharm/Tox, Discovery, Assay Validation, R&D Operations, Technical Operations, Regulatory Affairs


Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.

Nearest Major Market: Philadelphia

Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.


At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
3737 Market Street
Suite 1300
United States
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