Senior Scientist

Employer
Spark Therapeutics
Location
Philadelphia, Pennsylvania. Hybrid and remote options available for select opportunities.
Salary
Salary not provided
Closing date
May 28, 2022

View more

Discipline
Health Sciences, Drug Development
Job Type
Senior Scientist
Organization Type
Pharma

Job Details

The Senior Scientist will be part of the Pre-Clinical Bioanalytic (PCB) group, supporting multiple fast-paced non-clinical studies for advancing novel gene therapy programs across all Therapeutic Areas. The position requires strong scientific and technical skills in bioanalytical method development and preclinical sample analysis with a focus on immunoassays.

• Apply scientific and bioanalytical knowledge for developing method for various immunoassays such as biomarker, anti-drug antibody, cell-based neutralizing antibody (NAb) assay, and enzymatic activity assays to support the preclinical activities.

• Utilize high level of technical expertise and sound judgment for troubleshooting complex technical problems and finding appropriate solutions.

• Independently perform experiments and data analysis to support PCB workflow for bioanalytical assay development and preclinical sample testing to meet strict timelines.

• Experience with and/or ability to develop bioassays using various platforms such as ELISA, MSD-ECL, Gyrolab, and ProteinSimple Wes/ Jess.

• Prepare technical documentations as required.

• Mentor junior team members as appropriate.

Responsibilities

  • Hands-on laboratory work, plan and perform experiments, analyze data, and record experiments using good documentation practices.
  • Technical troubleshooting and finding suitable resolutions.
  • Mentor junior team members.
  • Participate in group discussions, advance bioassay capability and support PCB workflow.
  • Stay current with all required lab safety and compliance training.

Education and Experience Requirements

• M.S./ Ph.D. in a relevant field required.

• 3 to 5+ years laboratory experience in immunoassays.

• Experience in research, CRO and/ or industry environment.

• Extensive experience with bioassays and testing of biological samples.

• Extensive experience using analytical tools such as SoftMax Pro, Gen5, and Prism.

• Knowledge of regulatory requirements for GLP assays a plus.

• Experience with gene therapy a plus.

• Experience with liquid handler and/ or automation a plus.

• Experience with basic research a plus.

Key Skills, Abilities, and Competencies

• Excellent organizational and multi-tasking skills are required.

• Excellent interpersonal, writing, and verbal communication skills are required.

Complexity and Problem Solving

• Self-motivated, flexible, and willing to adapt to shifting priorities.

• Keen attention to detail and the ability to meet deadlines.

• Inter and Intra-team collaborations to support gene therapy programs.

• Must be comfortable in the fast-paced work environment and interact with multi-disciplinary research teams.

• Champion all safety aspects in the laboratories.

Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.


Nearest Major Market: Philadelphia



Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.

Company

At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
Website
Telephone
215-989-1149
Location
3737 Market Street
Suite 1300
Philadelphia
PA
19104
United States

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