Site Name: Upper Providence, USA - Pennsylvania - Upper Providence Posted Date: May 12 2022 GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. The Novel Human Genetics Research Unit (NHG RU) at GSK comprises a multidisciplinary biology team that utilizes deep scientific knowledge and technical capabilities to identify and validate novel therapeutic targets with human genetic association to diseases and undertake drug discovery efforts from early stage discovery through to phase 1 clinical trials. The NHG RU conducts drug discovery across a range of therapeutic areas including neuroscience, cardiovascular, renal, and metabolic diseases. We are seeking to hire a highly motivated biologist to fill a Senior Scientist position in the Novel Human Genetics Research Unit in R&D. The successful candidate will be part of a multidisciplinary team to establish and characterize cellular models derived from induced pluripotent stem cells (iPSCs), and to perform genetic perturbations (KD, KO, KI, overexpression) in iPSCs or iPSC-derived cells for drug discovery applications. The scientist will have the opportunity to work on targets and pathways relevant to a variety of human diseases and therapeutic areas. Details (Your Responsibilities): Conduct iPSC culturing, differentiation, and characterization. Utilize viral or non-viral delivery methods to achieve gene knockdwon or overexpression in iPSCs or iPSC-derived cells. Perform cellular assays for characterization of iPSC-derived cellular models Conduct RT-PCR, ELISA, Western, high content imaging, or reporter assays. Design and conduct experiments, analyze and report experimental data using a variety of laboratory instruments and computer softwares. Compliance with GSK policies including safety, electronic laboratory notebooks, and data integrity Maintain knowledge of relevant literature, and effectively incorporate knowledge and technology to positively impact projects. Clear communication of study results and with matrix teams Why You? Basic Qualifications: BS in Biological Sciences Two or more years of laboratory experience in molecular biology and/or cell biology. Two or more years of experience in cell culturing and genetic manipulation techniques including siRNA KD and gene overexpression. Two or more years of experience conducting cell-based assays (e.g. immune-sandwich, reporter gene assay, etc.). Two or more years of experience analyzing, summarizing, and interpreting experimental data and maintaining accurate/legible records. Preferred Qualifications: If you have one of the following characteristics, it would be a plus: MS in Biological Sciences Experience on iPSC differentiation into hepatocytes or a neural cell type Ability to execute experiments independently and work collaboratively with colleagues. Experience using viral vectors Experience with CRISPR genome editing technologies Experience with FACS cell analysis Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together. *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). 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