HT Analytical Research Associate
- Employer
- Spark Therapeutics
- Location
- Philadelphia, Pennsylvania. Hybrid and remote options available for select opportunities.
- Salary
- Salary not provided
- Closing date
- May 13, 2022
View more
- Discipline
- Life Sciences, Health Sciences, Drug Development, Analytical Chemistry
- Job Type
- Research Scientist
- Organization Type
- All Industry, Pharma
Job Details
- Execute routine analytical testing either manually or on automated liquid handlers according to laboratory protocols, including qPCR/dPCR, immunoassays, and cell-based methods.
- Under supervision of a group lead, coordinate testing schedule and associated activities for the HT testing team, and perform second scientist data reviews.
- Support maintenance and verification/calibration of laboratory equipment in collaboration with the lab automation team.
- Prepare assay reagents, maintain reagent and consumables inventory, and order lab supplies.
- Maintain good notebook documentation, perform data analysis, close-out experiments in a timely manner, monitor assay performance, and complete results and qualification reports.
- Support automation scientists in the automation and/or development of HT assays to support gene therapies, as needed.
- Minimum BS in engineering or life science discipline required, generally with 3+ years of experience in bioanalytical testing.
- Hands-on experience in at least one of the following methods is required: ELISA/immunoassays, qPCR/ddPCR, and/or cell-based potency assays.
- Experience working in a HT analytical lab and experience operating automated liquid handlers (e.g., Tecan, Hamilton, Beckman, Dynamic Devices) will be considered favorably.
- Experience in the analytical testing of large biomolecules (e.g. protein, nucleic acid, viral vector, virus, LNP) is preferred.
- General scientific knowledge of cell and molecular biology, biochemistry, and related analytical methods.
- Ability to effectively execute analytical protocols and perform data analysis.
- Ability to learn new techniques and work independently after training
- Capable of performing multiple tasks simultaneously
- Detail-oriented, with strong organizational and record-keeping skills
- Communicate and collaborate effectively in team setting
- Ability to propose solutions to lab issues and improve lab efficiency
- Ability to carefully execute experiments independently, analyze data, and learn new techniques.
- Comfortable in a fast-paced, high throughput lab environment, with ability to adjust quickly to changing needs of business.
- Able to troubleshoot problems of moderate complexity
- Work closely with Lab Automation for execution of automated testing workflows and for issues with automation equipment.
- Collaborate with functional area stakeholders to coordinate testing, provide updates, and deliver results on time.
- Position is a lab-based role and therefore requires the candidate to be on site the majority (> 80%) of time and to wear PPE as required by lab SOPs.
- Due to the inherent nature of experimental work, some extended hours / weekend work may be needed on occasion.
- Must be able to lift 25 pounds.
Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.
Nearest Major Market: Philadelphia
Join the Spark Team
We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.
We don't follow footsteps. We create the path.
Company
At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.
Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.
Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.
- Website
- http://sparktx.com/
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