Senior Associate Scientist, ASAP Purification

Employer
Pfizer
Location
Groton, Connecticut
Salary
Competitive
Closing date
May 19, 2022

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Discipline
Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
Pharma
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

The purpose of this position is to implement achiral and chiral singleton and library auto-purification in support of small scale synthetic chemistry efforts in Groton. As part of the Automated Singletons for Automated Purification group (ASAP) in Discovery Sciences, this position involves adapting the purification workflow for enabling analytical and preparative scale HPLC/SFC with MS triggered detection to enable purification of final compounds for submission to biological testing. Close collaboration with other purification scientists will lead to process improvements that increase efficiency and scope of auto-purification adapted to the purification of compounds that are diverse in their structures, molecular weight, and physicochemical properties. The individual occupying this role will assist in problem solving and developing separation methods to enable purification of singletons and libraries, coupled with providing analytical data to confirm identity and purity, and developing a variety of sample handling methods to deliver the purified compound in a format suitable for further testing/evaluation.

How You Will Achieve It

  • Implement analytical and traditional scale high throughput singleton and library purification using the PureLab Autopurification platform and software.
  • Prequalify submitted samples for purification and develop methods for separation using analytical LC/MS or SFC/MS instrumentation.
  • Manage the purification workflow that includes robotics and liquid handling technology using the Autopurification workflow and software.
  • Characterize purified compounds using analytical HPLC/MS/ELSD or SFC/MS/ELSD techniques and submit samples for testing using the compound management infrastructure.
  • Collaborate with purification team members to optimize the purification workflow for efficiency and scope of samples that can be purified.


Qualifications

Must-Have

  • Bachelor's degree in chemistry (analytical or organic) with 2-5 years of industry experience or Master's degree in chemistry (analytical or organic) with 1-3 year industry experience required.
  • Experience using UPLC/MS instrumentation to characterize compound mixtures.
  • Experience using preparative HPLC purification for purifying small scale quantities of organic compounds.
  • Knowledge of Liquid Handling and Weighing systems is preferred.
  • Experience using high throughput library/singleton HPLC/SFC/MS purification methods.
  • Experience using Waters Masslynx software.


Nice-to-Have

  • Knowledge of Nano LC and quantitation techniques will be helpful.
  • Experience using UPC2/MS instrumentation to characterize compound mixtures.
  • Experience using preparative SFC purification for purifying small scale quantities of organic compounds.

*Relocation support available

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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