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Senior Scientist, RNA Biotherapeutics Discovery Analytics

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Closing date
May 15, 2022

View more

Discipline
Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Senior Scientist
Organization Type
Pharma
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

We are seeking a highly motivated Senior Scientist to join the Molecular Assessment and Profiling group in BioMedicine Design as part of large molecule therapeutic discovery effort. The candidate will work with an innovative team of scientists to develop RNA-based therapeutics to bring curative treatments to patients. This individual will plan, execute and provide in-depth biochemical and biophysical characterization of RNA-based therapeutics in discovery research and development . In addition, this person will contribute to the development of innovative assays/methods for RNA/LNP physicochemical characterization. Successful candidate will work in a fast-paced environment managing multiple projects and contribute to team's deliverables.

How You Will Achieve It

  • Perform comprehensive molecular characterization, biophysical analysis, and stability assessment of RNA-based therapeutics
  • Critically analyze and present experiment results across multiple teams spanning general to subject expert audiences
  • Provide scientific guidance and decision to move project along discovery pipeline
  • Drive technology innovation; evaluate new technologies and instrumentations
  • Work closely with cross-functional teams including therapeutic discovery teams, production groups, MS and development organization to plan and execute deliverables


Qualifications

Must-Have

  • MS with 5+ years or PhD with 0-3 years of relevant experience in Molecular Biology, Biochemistry, Biophysics or related discipline
  • Knowledgeable with a wide range RNA and lipids nanoparticle characterization techniques including RNA integrity (5' capping, 3' polyA and CGE), chromatography techniques (SEC, RP-HPLC/UPLC), LNP lipid characterization, RNA packaging efficiency, zeta-potential charge and DLS size/PDI analysis
  • Hands on molecular biology experience with qPCR/ddPCR (including primer/probe design), method validation, assay development, and troubleshooting
  • Ability to manage multiple projects with overlapping timelines.
  • Highly organized, excellent communication, presentation and documentation skills


Nice-to-Have

  • Experience in therapeutic drug discovery and biochemistry research
  • Working experience with RNA and LNP analytics is highly desirable
  • Demonstrated track record of independent research and scientific publications in peer reviewed journals


Other Job Details
  • Relocation support available
  • Eligible for Employee Referral Bonus


#LI-PFE

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

#LI-PFE
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