We are seeking a highly motivated and accomplished investigative scientist to join our team in Global Discovery, Investigative & Translational Sciences in Drug Safety Research and Development, La Jolla CA. The successful candidate will have the opportunity to work jointly in both Translational Omics and Mechanistic Toxicology laboratories. You will have the opportunity to test a hypothesis using state-of-the-art Translational Omics platforms to discover and validate small and large molecules (RNAs, proteins, metabolites, lipids, etc.) as safety and/or disease monitoring biomarkers. As part of the mechanistic Toxicology group, you will be able to design and carry out investigative studies to explore underlying mechanisms for toxicity findings to advance molecules in preclinical and clinical development. We are seeking an individual contributor with strong critical thinking skills and a track record of Translational Omics and mechanistic investigations using cellular and molecular biology approaches. The successful candidate will have a strong background in state-of-the-art Translational Omics platforms, novel in vitro model development, fit for purpose assay design, and hypothesis-driven mechanistic research. This joint position will provide enhanced professional development with cross-functional team training opportunities.ROLE RESPONSIBILITIES
- Use cutting edge methodology/technology to discover, develop, validate, and translate novel mechanistic multiparametric biomarker panels to understand phenotypic safety and pharmacology.
- Leverage understanding of biological pathways and disease pathogenesis to create mechanistic insights from the analysis of integrated Translational Omics data and investigative research.
- Participate in primary cell gene editing work to support target safety de-risking
- Independently generates high quality laboratory-based investigative data to support portfolio progression and/or mechanistic understanding of toxicity findings
- Participate in issue management teams, work cross functional lines collaboratively as part of a global multi-disciplinary team
- Develops novel in vitro models and fit for purpose in vitro or in vivo endpoints
- Cross-trains other Translational Omics and/or investigative toxicology colleagues
- Communicates experimental findings accurately and concisely in both oral and written formats; analyzes, documents and reports laboratory data in accordance with company standards and procedures.
- Degree in Biology, Chemistry, Pharmacology, Toxicology, Biochemistry, Cell Biology or Molecular Biology is required.
- Bachelor's with 6+ years of full-time laboratory experience or Master's with 4+ years of research/pharma experience.
- Expertise in targeted gene modification techniques (e.g. siRNA, CRISPR)
- Expertise with mechanistic investigation of toxicity findings and fit for purpose biomarker development/evaluation, with a record of peer-reviewed publications and/or scientific presentations related to biological sciences.
- Hands-on experience in standard investigative laboratory capabilities, including cellular (primary cell culture), biochemical (enzymatic, plate-based assays), flow cytometry, RNA-based platforms and molecular (PCR, western blot) techniques.
- Strong attention to detail, communication, and organization skills. Team player with solid collaboration skills. Thrives in a fast-paced, dynamic, and mission-driven atmosphere.
- Bachelor's with 6+ years of full-time laboratory experience or Master's with 4+ years of research/pharma experience
- Hands-on experience with multiplex ligand-binding assay platforms (e.g., MSD, Quanterix, Bioplex/Luminex, Ella)
- Expertise in targeted gene modulation techniques such as base editing, and/or prime editing.
- Experience in therapeutic areas such as Oncology, Inflammation/immunology, and Rare Disease.
Lifting (reagent bottles, etc.), sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis. NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Relocation support availablePfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.Sunshine Act
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Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Research and Development