We are seeking a highly motivated and accomplished investigative scientist to join our team in Global Discovery, Investigative & Translational Sciences in Drug Safety Research and Development, San Diego, CA. The successful candidate will have the opportunity to work jointly in both Translational Omics and Mechanistic Toxicology laboratories. You will have the opportunity to use state-of-the-art omics platforms to discover and validate small and large molecules (RNAs, proteins, metabolites, lipids, etc.) as safety and/or disease monitoring biomarkers. As a key member of the mechanistic Toxicology group, you will be able to design and carry out investigative studies to explore underlying mechanisms for toxicity findings to advance molecules in preclinical and clinical development. We are seeking an individual contributor with strong critical thinking skills and a track record of translational Omics and mechanistic research using cellular and molecular biology approaches. The successful candidate will have a strong background in state-of-the-art omics platforms, novel in vitro model development, fit for purpose assay design, and hypothesis-driven mechanistic research. This joint position will provide enhanced professional development with cross-functional team training opportunities.ROLE RESPONSIBILITIES
- Use cutting edge methodology/technology to discover, develop, validate, and translate novel mechanistic multiparametric biomarker panels to understand phenotypic safety and pharmacology.
- Leverage understanding of biological pathways and disease pathogenesis to create mechanistic insights from the analysis of integrated omics data and investigative efforts.
- Lead primary cell gene editing work to support target safety de-risking
- Develops novel in vitro models and fit for purpose in vitro or in vivo endpoints
- Independently generates high quality laboratory-based investigative data to support portfolio progression and/or mechanistic understanding of toxicity findings
- Participates in issue management teams, work cross functional lines collaboratively as part of a global multi-disciplinary team
- Mentors and cross-trains other Omics and/or investigative toxicology colleagues
- Communicates experimental findings accurately and concisely in both oral and written formats; analyzes, documents and reports laboratory data in accordance with company standards and procedures.
- Represents Pfizer at external scientific meetings and consortia, demonstrate external engagement through high impact scientific publications
- PhD degree in Pharmacology, Toxicology, Biochemistry, Cell Biology or Molecular Biology required.
- Expertise in targeted gene modulation techniques such as CRISPR.
- Expertise with mechanistic investigation of toxicity findings and fit for purpose biomarker development/evaluation,
- Have a track record of peer-reviewed research publications and scientific presentations related to mechanistic research and biomarker discovery.
- Hands-on experience in standard investigative laboratory capabilities, including cellular (primary cell culture), biochemical (enzymatic, plate-based assays), flow cytometry, RNA-based platforms and molecular (PCR, western blot) techniques.
- Strong attention to detail, communication, and organization skills. Team player with solid collaboration skills. Thrives in a fast-paced, dynamic, and mission-driven atmosphere.
- Post-doctoral trainings or 1-2 years of pharmaceutical industry experiences preferred.
- Hands-on experience with multiplex ligand-binding assay platforms (e.g. MSD, Quanterix, Bioplex/Luminex, Ella)
- Gene editing including base editing and/or prime editing technologies
- Experience in therapeutic areas such as Oncology, Inflammation/immunology, and Rare Disease.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
- Lifting (reagent bottles, etc.), sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.
Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.Sunshine Act
- Relocation Support Available
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Research and Development