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Pharmacometricians permanent contract

F.Hoffmann-La Roche
Basel, Canton of Basel-Stadt (CH)
Closing date
May 29, 2022

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Job Details

At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. And we believe that good business means a better world.

That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. These positions are located in the Predictive Modeling and Data Analytics chapter, a chapter within the Pharmaceutical Sciences function, where Pharmacometrics is a primary focus area. We closely collaborate with our therapeutic areas and functions to convert hypotheses into innovative therapeutics.

As a pharmacometrician you contribute to developing medicines by designing and executing the pharmacometric strategy for programs in different stages of clinical development in one or more indication or disease areas. The pharmacometrics positions are located in the Predictive Modeling and Data Analytics chapter, where pharmacometrics is a primary focus area, together with other quantitative functions in Pharmaceutical Sciences. As a pharmacometrician you closely collaborate with other functions in pRED and development to ensure that the pharmacometric support is addressing the key needs to bring projects forward.

Your Responsibilities include:

  • Develop and execute scientifically sound, innovative and business-oriented Modeling & Simulation (M&S) strategic plans for projects in various disease areas and different stages of product development, including regulatory submissions.

  • Develop and execute appropriate (population) pharmacokinetic and (population) pharmacodynamic models for the project and apply, if available for the project, empirical and/or mechanistically-based drug disease models.

  • Conduct simulations to inform drug development decisions such as dosage regimen selection and other trial design features.

  • Communicate the outcome of M&S analysis to the project teams to support efficient discussion and decision making.

  • Contribute to responses to health authority requests and interactions to align on Clinical development and M&S strategy

  • Interact on a scientific level with partners in project team(s) with regards to all aspects of the application of M&S to ensure efficient and appropriate integration of M&S strategy and results into internal and external project documents (e.g. Clinical Development Plan, Investigator Brochure, NDA documents)


Your profile

  • MD, PharmD or PhD (in natural sciences, mathematics, physical sciences or engineering or any combination of these) with at least 3-5 years experience* in planning and conducting M&S projects for clinical study data in a pharmaceutical industry setting. 

  • Strategic mindset and understanding of how and when M&S can contribute value in drug development and support decision making.

  • Significant experience with M&S software (e.g. NONMEM, Monolix, Phoenix, MATLAB, Gastroplus, Simcyp, SAS, R,…)

  • Knowledge in technological advances like bayesian modelling and artificial intelligence (e.g. machine and deep learning) is desired as well as a keen interest for deep understanding of disease biology.

  • Ability to influence and lead without authority in a network organization

  • You exhibit a growth mindset. You ask for feedback and act on it. You embrace opportunities to gain new skills and perspectives and provide honest feedback to others to help them grow.

  • You are able to follow the science. You act on facts and data, not opinions and go where the science and the unmet needs of patients lead you.

  • Efficient written and oral communication.

  • You are able to radically simplify and prioritize for impact. You invest your time in things that accelerate progress for patients. You stop doing things that do not.

* The seniority level of the position will be determined based on the experience of the successful candidate


Your location

This position is located in Basel or in Welwyn.


You’re someone who wants to influence your own development. You are looking for a company where you receive the opportunity to pursue your interests across functions and geographies. Working in a multi-cultural environment motivates you. 

Are you ready to apply? We want someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche.

Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.


Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.


Job Level:

Individual contributor


About Roche

Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives. The combined strengths of pharmaceuticals and diagnostics under one roof have made Roche the leader in personalised healthcare – a strategy that aims to fit the right treatment to each patient in the best way possible.

Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system. Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management.

Founded in 1896, Roche continues to search for better ways to prevent, diagnose and treat diseases and make a sustainable contribution to society. The company also aims to improve patient access to medical innovations by working with all relevant stakeholders. Thirty medicines developed by Roche are included in the World Health Organization Model Lists of Essential Medicines, among them life-saving antibiotics, antimalarials and cancer medicines. Moreover, for the tenth consecutive year, Roche has been recognised as the most sustainable company in the Pharmaceuticals Industry by the Dow Jones Sustainability Indices (DJSI).

The Roche Group, headquartered in Basel, Switzerland, is active in over 100 countries and in 2018 employed about 94,000 people worldwide. In 2018, Roche invested CHF 11 billion in R&D and posted sales of CHF 56.8 billion. Genentech, in the United States, is a wholly owned member of the Roche Group. Roche is the majority shareholder in Chugai Pharmaceutical, Japan. For more information, please visit

All trademarks used or mentioned in this release are protected by law.

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