Gene regulation and cytokine biology in neuroinflammation
A postdoctoral position is available in the laboratory of Dr. Han-Yu Shih at the National Institutes of Health (NIH) in Bethesda, MD. Shih lab aims to understand the mechanisms that precisely regulate gene expression in lymphoid cells through multidisciplinary genomic approaches, including scRNA-seq, scATAC-seq, ChIP-seq and Hi-C. Lymphoid cells communicate the perturbation of homeostasis by production of cytokines, dysregulation of which results in neural and ocular inflammation in infectious, autoimmune and neurodegenerative diseases. The candidates will investigate immunoregulation of neuroinflammation using “omic” approaches, with the ultimate goal for identifying potential therapeutic targets.
This position offers exposure to multidisciplinary and cutting-edge genomic research and opportunities to collaborate closely with experts in immunology, neurobiology, and bioinformatics. The candidates will be leading/co-leading projects, designing experiments for generating high-dimensional data while working closely with collaborators and lab members. The candidate will be supported with an excellent intramural NIH fellowship in a stimulating and interactive research environment at NIH. Opportunities for training in bioinformatics as well as mentoring postbacs or summer students will be available based on interest. Salary is commensurate with research experience and accomplishments.
- Sciumè G, Mikami Y, Jankovic D, Nagashima H, Villarino AV, Morrison T, Yao C, Signorella S, Sun HW, Brooks SR, Fang D, Sartorelli V, Nakayamada S, Hirahara K, Zitti B, Davis FP, Kanno Y, O’Shea JJ, Shih HY. Rapid enhancer landscape remodeling and transcription factor repurposing enable high magnitude gene induction upon acute activation of NK cells. Immunity. 2020 PMID: 33010223
- Fernando N, Sciumè G, O'Shea JJ, Shih HY. Multi-Dimensional Gene Regulation in Innate and Adaptive Lymphocytes: A View From Regulomes. Front Immunol. 2021. PMID: 33841440
- Candidates must hold a Ph.D. or M.D./Ph.D. in immunology, neuroscience, genetics, molecular biology, biochemistry, computational biology or a related field, within three years of degree being awarded;
- Must have first authorship on at least one peer-reviewed publication;
- Must be self-motivated and keen to develop and/or learn cutting-edge technologies and/or up-to-date genomic data analysis;
- Experience in animal experiments, or NGS data analysis are preferred;
- The ability to work as part of a cohesive group is important as we are a highly collaborative lab;
- Have excellent writing and communication skills.
Interested candidates please send a cover letter, curriculum vitae, and contact information of three references to: NEI Shih Lab firstname.lastname@example.org
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