Postdoctoral Fellow

Postdoctoral research position, functional dependencies in very high risk acute lymphoblastic leukemia (ALL)

A priority of our research is to identify functional dependencies that drive drug resistance in very high risk leukemia to target the disease at the source. Using representative Patient-Derived-Xenografts for disease modeling we dissect the oncogenic program by integration of functional genomic and proteomic approaches to dissect the oncogenic program. We study defined genetic subtypes while modeling the bottleneck of resistance to anti-leukemic chemotherapy. Our data feed directly in an international clinical functional precision hematology program to which we contribute with drug response profiling to  develop new treatment options for patients with resistant hematologic malignancies.

About the Leukemia Research Group

Located in the Campus Lengg of the University of Zurich, we apply state-of-the-art technologies including single cell analytics, lab automation, machine learning, high-throughput data handling and ex-vivo / in vivo PDX models to deliver world-class preclinical and translational research. Our research is embedded in a strong precision oncology network, with strong ties with UZH and ETHZ. We are centrally involved in international precision hematology trials for childhood leukemia to provide the most relevant context to our research program.

In an agile and collaborative lab environment, with future professional growth prospects, the successful candidate will contribute with a strong appetite for scientific discovery and an independent while cooperative mindset. A strong interest for system’s biology and biomedical computing as well as strong laboratory expertise is required. Innovative and actionable ideas are encouraged and supported.

Activity profile

• You are a key member of a dynamic group that study highly relevant questions in cancer biology with immediate impact for patients. 
• You engage with functional genomics, oncogenic transcription and systems biology
• You have a strong experimental track record. 
• You are hardworking, flexible and proactive.
• You bring a solid background in molecular genomics and computational approaches.
• You are motivated to work together with a focused task force and to guide master and PhD students.

Requirements

• MD-PhD or PhD in biological or biomedical sciences or equivalent 
• Special interest in cancer genetics, oncogenic transcription and systems biology 
• Strong analytical and problem-solving skills.Comfortable with planning, prioritizing, conducting, analyzing and communicating research in a variety of contexts.
• Excellent verbal/written communication and interpersonal skills with the ability to communicate effectively with all collaborators, colleagues and team members.
• Proficiency in English.

• Experience with complex bioanalytical tools. 

The lab

• Young innovative international team
• Dynamic and growing research environment with 40+ researchers in cancer biology
• international academic network with track record of clinical impact

Position available immediately 

Please send motivation letter and CV including references to

manilay.wiesner@kispi.uzh.ch

Assistant to Professor Jean-Pierre Bourquin

Division Head, pediatric Hematology-Oncology, University Children’s Hospital Zurich

Research Campus Lengg

https://publons.com/researcher/2804117/jean-pierre-bourquin/