Institute Research Investigator Drug Metabolism and Pharmacokinetics

University of Texas MD Anderson Cancer Center
Houston, Texas
Closing date
Jun 5, 2022

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Health Sciences
Organization Type
Within The University of Texas MD Anderson Cancer Center lies a powerful engine driving the future of new targeted, immune- and cell-based therapies: the Therapeutics Discovery Division. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery, with a multidisciplinary team of dedicated researchers, doctors, drug developers and scientific experts working together to develop small-molecule drugs, biologics and cellular therapies. Our unique structure and collaborative approach allow the team to work with agility, bringing novel medicines from concept to clinic quickly and efficiently - all under the same roof.

The Therapeutics Discovery Division is built around four platforms: The Institute for Applied Cancer Science (IACS), ORBIT (Oncology Research for Biologics and Immunotherapy Translation), TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology) and the Neurodegeneration Consortium.

The IACS platform is focused on discovering and developing the next generation of small-molecule targeted therapies, driven by the needs we see in our patients. The team aligns world-class drug discovery and development research with the science and clinical care for which MD Anderson is known. We work in a fast-paced, milestone-driven environment with a focus on team science and interdisciplinary research. Our unique approach has created a biotech-like engine within the walls of the nation's leading cancer center to bring life-saving medicines to our patients more quickly and effectively. This model already has achieved results, with multiple programs currently in clinical and late-stage preclinical development.

The Institute Research Investigator in the ADME/PK Group contributes to the advancement of IACS small molecule drug discovery projects by conducting in vitro ADME/PK studies. The scientist will enable advancement of projects through leadership and experimental activities. The position requires a highly self-motivated individual, with outstanding organizational and communication skills. The ability to work well under pressure and drive towards individual and team objectives that impact critical timelines is expected. A collaborative attitude is essential for the position.


• Independently execute in vitro ADME assay efforts on drug discovery programs, including microsomal and hepatocytic stability assays, DDI, TDI, and cell permeability.
• Develop, validate, and execute new assays (enzyme and cell-based) as needed. Troubleshoot issues with assay performance and monitor assay quality.
• Responsible for analytical method development, validation, and qualification for a large variety of small molecules. Quantify analytes in various biological matrices using state-of-the-art mass spectrometry techniques.
• Track and ensure the timely execution of analytical studies from sample receipt, sample preparation, and date analysis, through to report delivery.
• Serve as the ADME/PK representative on project teams. Interact effectively with these cross-functional teams towards the optimization of drug candidates with optimal ADME-PK properties and serve as a point of contact on the programs.
• Write validation protocols and reports; maintain accurate research records and laboratory notes;
• Independently propose innovative solutions to research projects and contribute to project goals through laboratory experiments.
• Apply and develop cutting edge basic science tools and methodologies to develop complex strategies and enable advancement of Institute projects through leadership and experimental activities.
• Mentor research associate scientists.
• Contribute to external presentations and publications.

Required: Bachelor's degree in biology, biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.

Preferred: Master's degree or PhD in biology, biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.

Required: Six years experience of relevant research experience in laboratory With Master's degree, four years of required experience. With a PhD in a natural science or Medical degree, no experience required.

Hands-on laboratory experience in relevant industrial/academic lab. Previous experience with LC-MS/MS including method development, optimization, validation, and troubleshooting. Previous experience with in vitro ADME assays (enzyme and cell-based). Experience in using automated liquid handling and other automation would be beneficial. High attention to detail and ability to maintain clear records of experimental work is critical. Demonstrated ability to work in a team-orientated environment. Familiarity with regulatory bioanalytical SOP requirements.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.

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