Postdoctoral scholars in ion channel diseases

The Department of Physiology & Biophysics at Case Western Reserve University School of Medicine seeks a highly motivated postdoctoral scholar to conduct research in the laboratory of Dr. Tingwei Mu (https://physiology.case.edu/people/faculty/tingwei-mu/). Case Western Reserve University School of Medicine ranks #24 according to the newest US News and World Report (https://www.usnews.com/best-graduate-schools/top-medical-schools/case-western-reserve-university-04086).

The Mu lab focuses on proteostasis maintenance of membrane proteins in the central nervous system. Membrane protein folding and misfolding is an emerging field in the medical science field. We use a combination of neuroscience, cell biology, and electrophysiology approaches to study how the proteostasis network regulates the folding, degradation, assembly, trafficking and function of neuroreceptors both in vitro and in vivo. Another research focus of the lab is the development of therapeutics that correct the misfolding of pathogenic ion channels, as a therapeutic strategy for the treatment of such protein conformational diseases, including neurological and neurodegenerative diseases.

The successful applicant will participate in projects on elucidating molecular basis of ion channel protein quality control in the endoplasmic reticulum. The qualified candidate will also be part of our drug discovery project for neurological diseases. The posted positions will be supported by a NIH NINDS R01 grant. Competitive salary will be provided and commensurate with experience.

The applicant must have a PhD and/or MD degree in neuroscience, cell biology, molecular biology, biochemistry, biophysics, pharmacology, or related field. Previous experience with mouse genetic models or neuroreceptors-related research is desired, but not required.

Interested individuals should send a cover letter, CV, and the names/phone numbers of three people who could provide letters of reference by email to tingwei.mu@case.edu.