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Institute Associate Scientist II - Medicinal Chemistry

University of Texas MD Anderson Cancer Center
Houston, Texas
Closing date
Jun 14, 2022

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Health Sciences
Organization Type
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The mission of The University of Texas M. D. Anderson Cancer Center is to eliminate cancer in Texas, the nation and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public.

MD Anderson is known for providing cancer patients with exceptional care, which includes early access to innovative new treatments through clinical trials. The Institute for Applied Cancer Science (IACS) within the Therapeutics Discovery Division is a hybrid model that uniquely combines the drug discovery capabilities of the biopharmaceutical industry and the extensive knowledge of biology found in academia with the expertise of MD Anderson's top clinicians. IACS has the singular goal of rapidly developing novel, effective and safe therapeutics that improve patient health. IACS executes programs with the highest probability of clinical success in a rigorous, goal-oriented, data-driven manner.

The Institute Associate Scientist II, Medicinal Chemistry, participates in cross-functional research to discover novel oncology therapeutic agents that benefit patients. He/She will be a highly creative synthetic chemist with a strong desire to succeed at the highest level, and will be responsible for the synthesis of small molecule targets to advance IACS oncology drug discovery projects to the next generation of cancer therapeutics.


1. Under moderate supervision, conduct laboratory experiments to synthesize novel small molecules and support target validation and lead optimization activities within drug discovery projects.
2. Execute a variety of organic chemistry manipulations, including those with air sensitive and hygroscopic reagents; perform routine purification of intermediates and final products utilizing techniques such as HPLC, flash chromatography; characterize compounds using analytical instrumentation such as HPLC, LCMS, and NMR.
3. Efficiently execute multistep syntheses, and productively synthesize analogs. Perform scale-up operations.
4. Efficiently plan ahead for requirements and smooth execution of multistep syntheses; efficiently manage weekly workload and assignment deadlines.
5. Under moderate supervision carry out retrosynthetic analyses to design or optimize synthetic routes to targets.
6. Under moderate supervision trouble-shoot synthetic problems and propose viable synthetic modifications.
7. Propose new synthetic targets, and contribute to the design of new small molecule modulators of protein targets.
8. Leverage latest synthetic approaches, parallel chemistry and purification techniques.
9. Participate in integrated drug discovery research activities by interacting with scientists of different disciplines.

Required: Bachelor's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.

Preferred: Master's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.

Required: One year of relevant research experience in lab. With preferred degree, no required experience.

The ideal candidate will have a Master's degree in organic or medicinal chemistry with expert knowledge in synthetic organic chemistry, with demonstrated ability to conduct challenging multi-step organic chemistry syntheses and overcome synthetic hurdles. Demonstrated team player who possesses excellent problem solving capabilities, and can contribute to the success of projects with moderate supervision.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.
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