Staff Scientist - Radiation Oncology and Immuno-Oncology

City of Hope
Duarte, California
Closing date
May 28, 2022

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Life Sciences, Oncology, Physical Sciences, Chemistry
Position Type
Full Time
Organization Type

Job Details

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope's translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope's specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation's "Best Hospitals" in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope's commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary:

A staff scientist position is available in the laboratory of Dr. Heather McGee, MD, PhD, Assistant Professor in the Departments of Radiation Oncology and Immuno-oncology in the Beckman Research Institute at City of Hope. The staff scientist must be interested in tumor immunology and the immune response to radiation in multiple cancer types, including hepatocellular carcinoma, colorectal cancer, pancreatic cancer and lung cancer. Research in the McGee lab spans the entire spectrum from cell culture experiments with cancer cell lines, to murine experiments with transgenic mouse models and knock-in reporter mice, to imaging studies with patient samples. The staff scientist will utilize techniques including murine irradiation, multicolor flow cytometry, multi-plex immunofluorescence, microscopy, and scRNA sequencing to dissect biologic mechanisms activated by radiation that influence the local immune response in various tumor microenvironments. The staff scientist will play a leading role in NIH-funded research and have the opportunity to be first author on multiple presentations and publications that stem from this work.

Dr. McGee is looking for a staff scientist who is eager to be challenged scientifically, hone his/her critical thinking skills and test new hypotheses in creative ways. Dr. McGee emphasizes mentorship and plans to work closely with all members of the lab to ensure that they feel like valued members of the team. Dr. McGee is eager to mentor staff scientist of all backgrounds who want to go on to develop a productive career in academic medicine or science and will provide career opportunities to help the staff scientist achieve his or her career goals.

The long-term goals of the McGee lab are to identify key molecular and immunologic pathways that can be targeted to enhance the immune response to radiation and develop personalized medicine approaches for cancer patients treated with radiation. The staff scientist will play a key role in all steps of this process with the potential to apply their pre-clinical research findings to patients in a future translational study.

Basic education, experience and skills required for consideration:
  • The Staff Scientist must possess, at a minimum, the U.S. equivalent Bachelor's or Master's degree in immunology, cancer biology or a related discipline, and will often have a Ph.D. or other doctoral level degree.
  • Have at least 1 first author publication.
  • Experience in cellular immunology is required.
  • Proficiency with murine tumor models and multicolor flow cytometry is required.
  • A desire to work in a collaborative, interdisciplinary lab environment that values creativity, initiative, hard work, professionalism, and teamwork is required.

Additional Information:
  • Dr. McGee's research is supported by an NIH/ NCI R00 grant from the National Cancer Institute and a generous start-up package from City of Hope.
  • Research findings from Dr. McGee and colleagues have been published in Nature , Nature Communications , Clinical Cancer Research , Journal of Immunology , Journal for Immunotherapy of Cancer , International Journal of Radiation Oncology* Biology* and Physics , and numerous other journals.
  • As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research.  City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

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