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Postdoctoral Fellow - Leukemia Cell Survival

City of Hope
Monrovia, California
Closing date
Jul 7, 2022

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Life Sciences, Cell Biology
Position Type
Full Time
Organization Type
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Job Details

Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions.

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope's translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope's specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation's "Best Hospitals" in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope's commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow in the Department of Systems Biology. This lab studies drug resistance in leukemia and how the microenvironment contributes to this: leukemia cells can become resistant to drug treatment because they obtain support for their growth and survival from stromal cells in the bone marrow. This lab studies the molecules and mechanisms that are responsible for this type of drug resistance development.

This lab works with leukemia in tissue co-culture with stromal cells, cell imaging, retroviral or lentiviral transduction, Cas/CRISPR knockout, FACS, and mice. Candidates who are interested in following an academic career path, are self-motivated and enjoy the complexity of biological systems are especially encouraged to apply. It is important for us that you can work well with others.

Key Responsibilities
  • Participate in project planning, experimental design, data generation, data interpretation and evaluation, and communication of results related to our studies how leukemia cells escape eradication by drug treatment;
  • Communication of results includes acquiring manuscript writing skills and publishing papers on the obtained results in peer-reviewed journals;
  • Develop grant writing skills and participate in seminars, lectures, poster sessions and presentations at national meetings;
  • Provide guidance to junior lab members, develop new methods and protocols for research and assist with the development of other projects in the lab.

Basic education, experience and skills required for consideration:
  • A Ph.D. degree in life or biomedical sciences, or a related discipline is required;
  • Experience in working with hematopoietic cells in tissue culture.

Preferred education, experience, and skills:
  • Expertise in glycobiology is an advantage but not required.

Additional Information:
  • The location of the lab at the Monrovia Campus of the Beckman Research Institute within the Department of Systems Biology provides many opportunities to interact with others who study leukemias;
  • The lab also has ongoing collaborations in the area of glycobiology with scientists at the Institute for Glycomics, Griffith University, Australia;
  • For more information, please visit Dr. Heisterkamp's lab here:
  • Please include an updated CV, a 1-page cover letter describing your current position, your reasons for applying and contact details of three recent referees as a single PDF.

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

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City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research.  City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

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