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Molecular Clinical Variant Curator

City of Hope
Duarte, California
Closing date
May 17, 2022

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Life Sciences, Molecular Biology
Position Type
Full Time
Organization Type
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Job Details

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope's translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope's specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation's "Best Hospitals" in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope's commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Key Responsibilities include:

Use comprehensive knowledge of scientific theory and departmental policies and procedures to curate genetic variants/mutations detected through standard molecular genetic testing using information from existing databases and from literature.
  • Understand and comply with policies and procedures to perform responsibilities.Recognize, troubleshoot and resolve problems/adverse situations utilizing analytical thinking skills.
  • Guide and assist other staff in resolution of complex technical problems, recommending actions and evaluating outcomes.
  • Evaluate, validate, and complete requirements for new method and instrumentation in conjunction with department leadership.

Participate as a productive member of the work team.
  • Contribute to the productivity of the work team through adaptability and flexibility to workload and schedule changes in a way that promotes cooperation and minimizes disruption to the work environment and complies with the organization and departmental attendance policies.
  • Coordinate a simultaneous series of tests with complete accuracy in a timely manner and demonstrate a low error rate and test repeat rate.
  • Handle the normal workload in an organized and efficient manner and multitaskto handle heavy workload as needed
  • Actively assist coworkers with additional workload as time permits.

Curate genetic variants/mutations applicable to the CMDL offerings
  • Review clinical sequencing data output and assist in identifying sequencing artifacts.
  • Use public databases and in-silico tools to determine impact of the variant on the protein function.
  • Read scientific literature to identify and curate the functional outcomes of variants in population level.
  • Assist in classifying variants to different pathogenicity levels based on prior Information.

Basic education, experience and skills required for consideration:

Minimum Education:
  • Master's Degree in Biological Sciences and familiarity with Germline databases, Sanger Sequencing and Next-generation sequencing (NGS) or
  • Bachelor's Degree and familiarity with Germline databases, Sanger
  • Sequencing and Next-generation sequencing (NGS) and 2 years of sequencing data interpretation.

Minimum Experience:
  • Knowledge of principles and practices of computational biology as applied to genetics/genomics. An understanding of bioinformatics analysis to identify variants within genomic data sets, and variant effect prediction algorithms. Laboratory and/or clinical experience in cancer genetics. The ability to critically read, understand, and interpret data from scientific publications. Cross-disciplinary and strong analytical skills as well as broadexperience using computational methods, databases, software and hardware.

Preferred Experience:
  • 2 years of sequencing data interpretation is desirable with Master's Degree in Biological Sciences

Additional Information:
  • Full Time
  • As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research.  City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

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