Postdoctoral Research Position at University of Pennsylvania-Human tumor immunology

Postdoctoral Research Position at University of Pennsylvania-Human tumor immunology

Employer: University of Pennsylvania, Perelman School of Medicine

Location: Philadelphia, PA

Salary: Based on NIH postdoctoral stipend level, Commensurate with experience

Job Description:

We are seeking a highly devoted and enthusiastic PhD scientist to join our group as a postdoctoral research fellow to study the myeloid cells and their functional cross-talk with tumor-specific T cells and NK cells in human tumor microenvironment. The myeloid cells represent a significant portion of these inflammatory cells in the tumor microenvironment and influence nearly all steps of tumor progression in mouse tumor models. However, the characterization of the tumor microenvironment in human is still in its infancy and the relative contribution of individual myeloid cell populations into inhibition or promotion of tumor expansion in human remains largely unexplored. Thus, potential candidate will be involved in investigating the role of the inflammatory myeloid cells in the human lung tumor microenvironment and the cellular and molecular mechanisms by which tumor modulates their immune functions in cancer patients. This position provides an excellent career development opportunity to work with a dynamic group of tumor immunologists as well as opportunity to learn new methods and approaches.

Specifically, He/She will investigate the role of the human tumor-infiltrating macrophages and neutrophils in the regulation of tumor-specific T cell and NK cell responses in lung cancer patients Also, He/She will investigate the ability of tumor-associated neutrophils and macrophages to regulate tumor-targeting mAb-triggered immune responses. The potential candidate will also study the mechanisms underlying in anti-tumoral activity of newly discovered subset of APC-like tumor-associated neutrophils. Please see our recent publications for more details: Singhal et al, Cancer Cell, 2016; Singhal et al, Science Translational Medicine, 2019. We offer a competitive salary and an excellent benefits package.

Responsibilities:

Postdoc fellow will perform all basic immunological assays including the flow cytometry-based assays, tissue cell culturing, processing human specimens, cytokine multi-plex assay, western blot, ELISA, ELISpot, cytotoxic assays and others. Skills in a molecular biology such as DNA/RNA extraction and analysis, standard and quantitative PCR, conventional and next-generation sequencing are desired. Also, there is a great opportunity to learn new methods and approaches to study human tumor microenvironment. The postdoctoral fellow is expected to participate in design and performing experiments, data analysis and presentation. The candidate will work independently to manage daily research projects, data collection and organization of the laboratory. He/she must be able to identify and resolve technical problems and use analytical and decision-making skills to implement assigned projects. He/she will be required to write up the manuscripts.

Preferred Qualifications: PhD, Experience in cancer biology and tumor immunology

Basic Qualifications: Ph.D./M.D. in Immunology.

Please contact Dr. Eruslanov (evgeniy.eruslanov@pennmedicine.upenn.edu) directly with CV and cover letter with research interests or apply here:

https://www.med.upenn.edu/apps/my/bpp_postings/index.php?pid=28211