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Staff Scientist, Cancer biology and genetics

National Cancer Institute, Laboratory of Pathology
Bethesda, Maryland (US)
Salary is commensurate with experience
Closing date
Jun 22, 2022

View more

Life Sciences, Cancer Research
Position Type
Full Time
Job Type
Research Scientist, Senior Scientist, Staff Scientist
Organization Type
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The Laboratory of Pathology, Center for Cancer Research (CCR) of the National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, MD, is actively recruiting for a Staff Scientist to work in the Cancer Molecular Pathology section headed by Frederic G. Barr, MD PhD. This research section uses a multidisciplinary approach involving genomics and bioinformatics along with cell culture and animal models to study genetic and epigenetic alterations in cancer. By initially focusing on specific cancer types, such as the rhabdomyosarcoma family of myogenic soft tissue cancers, this research laboratory is investigating the molecular basis, biological consequences and clinical significance of chromosomal translocations, amplification events, point mutations and methylation changes in these cancers. The methodologies, reagents and concepts from these studies are then being applied to address these issues in other relevant cancer categories. Recent projects in the laboratory are in the areas of:

1) Action of fusion oncoproteins (J. Pathol. - PMID: 28138962)

2) Mechanisms of tumor recurrence (Cancer Res. - PMID: 33589519)

3) Amplified genes as therapeutic targets (J. Clin. Invest. - PMID: 34166228)

4) DNA methylation-based classification (Int. J. Cancer - PMID: 30565669).

The selected candidate will work closely with a team of researchers in the Cancer Molecular Pathology section and will promote and support numerous interdisciplinary collaborations both within and outside the NIH. This is an exciting opportunity to join a growing and evolving cancer research effort across the basic, translational, and clinical research spectrum. The successful applicant will provide demonstrable leadership and mentoring in the planning, execution, interpretation and communication of research projects in the Cancer Molecular Pathology section. The selected candidate will also work closely with the section head to identify future research opportunities and develop a strategic plan to achieve these goals.

The CCR is an intramural research component of the NCI. CCR’s enabling infrastructure provides extensive opportunities for collaboration with other investigators at the forefront of medical research. This environment enables scientists and clinicians to undertake high-risk, high-impact, laboratory- and clinic-based investigations. Investigators are supported by a wide array of intellectual, technological, and research resources, including surgical and pathology facilities; animal facilities; and dedicated, high-quality technology cores.

Please submit CV including list of publications, cover letter including summary of research experience, and names/contact information of three references to Review of applications will begin on or about April 11, 2022, and the position will remain open until filled.

DHHS, NIH, and NCI are Equal Opportunity Employers. The NIH and NCI are dedicated to building a diverse community in its training and employment programs.

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