The Human Neuronal Differentiation and Stem Cell Core (HNDSCC) is looking for an independent and self-motivated scientist to join an expert research team focused on delivering human cell culture models to investigators across Texas Medical Center. The research integrates various experimental approaches using human cell culture models of disease with analyses from patient and control subject cohorts. The Research Associate role requires a capacity for project planning and management while working under minimal supervision on applying and developing standard operating protocols for pluripotent stem cells reprograming, genome editing, differentiation to various progeny types and phenotypic characterization of these models. Previous relevant training and ability to work in multidisciplinary teams with Baylor investigators utilizing human stem cells in basis and clinical research is critical. Training, mentoring, and management of research assistants and core users will be part of daily schedule. Ideal candidate will have strong experimental track record in working with human induced pluripotent and embryonic stem cells. We welcome applications from MS and PhD levels. This is a research staff position for an Institutional Core Facility that provides opportunities for long term stable employment and career growth.
The core facility is part of BCM Advanced Technology Cores and is located at the Neurological Research Institute of the Texas Children's Hospital, a multidisciplinary and extremely dynamic research environment with state-of-art infrastructure. Job Duties
- Plan and complete advanced research experiments including cell cultures and perform routine biochemical, genetic, and molecular biology techniques (Western blotting, qPCR, and DNA cloning)
- Handle and process biological specimen (blood, skin biopsies)
- Train and supervise members of the research team in the conduct of advanced experiments, including pluripotent stem cells derivation, precise genome editing of stem cells and subsequent studies of downstream target cell types differentiated from stem cells (e.g. neuron or glial)
- Handle / process human tissue samples (e.g. blood or skin biopsy specimens) used to generate stem cells
- Manage lab orders and regent preparation performed by core's research assistants
- Training in specialized research methods will be provided as needed
- Master's degree in Basic Science or a related field. Experience in lieu of degree will not be accepted.
- Three years of relevant experience typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.
- PhD in Biology/Molecular Biology/Biochemistry/Neurobiology or related field.
- At least two years of direct experience with iPSC cell culture is required for PhD-level applicants.
- Advanced PhD with some post-doctoral research experience.
- Experience with neural/glial differentiation of hPSC is a plus.
- Experience with CRISPR/Cas9 genome editing on human iPSCs is extremely valuable.
- Extensive research experience in cell biology, molecular biology, genetics, or neuroscience.
- Mentoring or teaching experience is a plus.
- Essential personal qualities important for this job include great interpersonal skills, excellent time management and organizational abilities, sense of responsibility and scientific integrity, clear and effective verbal / written communication and reporting skills, interest in working in a fast-paced team environment to collect, document, analyze and publish experimental results.
Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.