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Senior Associate Scientist, BMD Biotherapeutic Production

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Closing date
Feb 2, 2022

View more

Discipline
Physical Sciences, Chemistry, Other, Manufacturing/QA/QC
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
Pharma
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

Pfizer's BioMedicine Design (BMD) is seeking a highly motivated Biochemist/Molecular Biologist to join Biotherapeutic Expression and Purification group (BEP) in Cambridge, MA. Qualified candidate will play an essential role in a high-energy DNA and RNA production and protein expression research laboratory. The group supports non-GMP transient protein and RNA lead production across Pfizer's diverse biotherapeutic discovery portfolio to enable Pfizer's research units and their pre-clinical therapeutic in-vitro and in-vivo needs. The candidate is expected to have a strong background in molecular biology techniques including vector design and cloning as well as experience with nucleic acid production and analysis. The candidate will be responsible for leading vector DNA production and process development to support large-scale production of RNA modalities using state-of-the-art technologies and equipment. The candidate will contribute to the group wide deliverables and be required to work on several projects simultaneously presenting results and updates at group meetings.

How You Will Achieve It

  • Production and manipulation of plasmid DNA to support scale-up production of RNA therapeutic candidates
  • Develop processes for therapeutic RNA analysis using molecular biology and cell-based assays
  • Drive technology innovation; design and conduct testing of new process methods, technologies, and products for nucleic acid production
  • Work closely with multidisciplinary teams including therapeutic discovery teams, research units, bioanalytical teams, and R&D project leads
  • Prepare, evaluate, and present data internally to cross functional teams


Qualifications

Must-Have

  • Bachelor's Degree in Biochemistry, Biology, Biomedical Sciences or a related discipline with 3-5 years of relevant experience or Master's Degree in Biochemistry, Biology, Biomedical Sciences with 0-2 years of relevant experience along with an understanding of biotherapeutic production
  • Experience with bacterial and mammalian cell lines and cell culture, transfection, and cell-based assays
  • Proficiency in nucleic acid purification and quantitative analysis techniques
  • Experience and strong background in molecular biology techniques such as vector design, PCR, nucleic acid purification, cloning, and sequence analysis among other more advanced molecular biology techniques
  • Familiarity with Geneious or other vector mapping software
  • Strong organizational and communication skills, written and oral


Nice-to-Have

  • Experience with flow cytometry, ELISA, immunoblotting, and luciferase assay
  • Familiarity with digital and lab automation


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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