Senior Scientist, Antibody Discovery, BioMedicine Design

Role Summary

BioMedicine Design of Pfizer Inc. is seeking a highly motivated antibody discovery Scientist in La Jolla, CA. This Scientist level position will directly contribute towards our efforts for discovery of monoclonal antibodies using hybridoma technologies. The candidate will support different antibody discovery programs while utilizing a broad range of immunology, molecular biology and cell biology-based techniques. The duties of the job include experimental design and execution, analysis and interpretation of data, and presentation of results to the research team. This position will be exposed to the state of art technology in single cell analysis, NGS sequencing and the advanced automation system.

Role Responsibilities

• Design and execute on all stages of experiments to generate monoclonal antibodies through hybridoma or display technology, including animal immunizations, serum titer tracking, hybridoma or immune library generation, and candidate identification.
• Sequence the VH and VL of antibody hits, analyze antibody diversity, and choose representative clones for recombinant production.
• Regular cell culture and maintenance. Transient expression of antibodies in mammalian cells. Small scale purification of recombinant antibodies.
• Interface with external CROs to identify need for reagents, define timelines and scheduling to meet project goals.
• Maintain detailed records of all experiments in ELN and using in-house databases and tracking systems
• Trouble-shoot and optimize protocols and propose creative solutions to improve efficiency to existing processes
• Proactively evaluate new technologies, instrumentation, and assays available from the literature or scientific meetings to improve in-house platforms

BASIC QUALIFICATIONS

• MS or PhD degree in a relevant scientific discipline (biology, immunology, biochemistry, cell biology etc.). PhD with 0-2 years, or MS with 4+ years.
• The candidate must have in-depth knowledge of current state-of-the art antibody generation technologies and be able to apply this to practice at the bench
• In depth understanding of immunology, cell biology, and molecular biology is needed as well as a thorough understanding of approaches to manipulate immune response and characterize antibodies (both binding assays and sequence analysis)
• Demonstrated experience successfully executing antibody generation using hybridoma or display technology to identify antibody panels is required
• Extensive experience with antibody binding assays especially ELISA, multi-color flow cytometry.
• Strong experience in Excel, Graphpad Prism, flow cytometry analysis software is required.
• Strong focus, motivation, and commitment to hands-on lab work is required
• Good organizational skills, with scientific rigor and critical thinking.

PREFERRED QUALIFICATIONS

• NGS related experience is a plus.

Other Job Details:

• Last Date to Apply: February 28, 2022
• Eligible for Relocation Package: Yes
• Eligible for Employee Referral Bonus: Yes

#LI-PFE

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

#LI-PFE