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Scientific Leader, Biophysics, Encoded Library Technologies

Cambridge, MA
Closing date
Jan 27, 2022

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Life Sciences, Biophysics, Physical Sciences, Chemistry
Organization Type
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Site Name: USA - Massachusetts - Cambridge Posted Date: Jan 25 2022 GSK is seeking an Associate Director - Biophysics, Encoded Library Technologies to join our team at the Cambridge, MA Discovery Hub. This role will be accountable for delivering DNA Encoded Library selection optimization protocols as well as protein construct qualification and small molecule and protein interactions studies in support of the GSK discovery project portfolio (20+ projects per year). In addition to the project direct work, the role is accountable for all operational aspects of maintaining an effective biophysics infrastructure, active lifecycle management and exploration of new technologies. Key Responsibilities: Group leadership of Biophysics team Development of methods to optimize selection protocols for DNA encoded libraries, including molecular proximity and covalent strategies. Accountable for managing the prioritization, quality and communication of Protein Construct Assessment for incoming targets Accountable for managing the prioritization, quality and communication of small molecule : protein interaction studies in support of ELT projects Accountable for all operational aspects of maintaining an effective biophysics infrastructure, active lifecycle management and trouble shooting Primary Liaison with Biophysics functions at other GSK R&D hub sites Create documentation, training materials and communication templates for projects with respect to the accountabilities Contribute to research of new methodologies as they apply to Encoded Library Technology and contribute to strategic planning discussions outside of key accountabilities Represent GSK externally at conferences and through publication in peer reviewed Journals Recruit, retain and develop scientific talent Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: PhD or MS in life science with at least 5 years of drug discovery experience Experience developing assays with SPR, MST, switchSENSE or similar to characterize protein:protein or protein:small molecule interactions Experience leading teams to deliver binding assay data for early stage drug discovery projects Preferred Qualifications: If you have the following characteristics, it would be a plus: Familiarity with DNA-encoded Libraries, Aptamer or other biological selection/panning techniques High throughput data analysis and interpretation skills Familiarity with small molecule or biological mass spectrometry Data analysis related programming in R or Python Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
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