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Senior Associate Scientist, Translational Gene Therapy AAV (non PhD)

Cambridge, Massachusetts
Closing date
Feb 1, 2022

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Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
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What You Will Achieve

Pfizer's Rare Disease Research Unit (RDRU) focuses on developing drugs for treating rare diseases. The Gene Therapy Translational Research group is part of the RDRU focused on gene transfer approaches to treat rare genetically defined diseases that focus on the CNS, neuromuscular, and liver (systemic and metabolic) therapeutic areas. The Senior Associate Scientist will work as part of a team to explore Pfizer's RNA based approaches to treat rare diseases. As a member of the team developing RNA therapeutics you will perform biochemical and molecular biological assays to create and evaluate constructs in vitro and in vivo. The role requires extensive knowledge and expertise in plasmid design, cloning, RNA methodologies, PCR assays, cell culture, ELISA, and Flow cytometry. Experience with next generation sequencing and data analysis is preferred. The Senior Associate Scientist will write protocols, perform the studies, write reports and present their work to team members.

How You Will Achieve It
  • Design plasmid constructs utilizing a variety of molecular biology techniques
  • Execute in vitro and vivo studies
  • High throughput screening of disease targets
  • Perform various biochemical, cell biology, molecular biology, and immunology assays
  • Communicate findings to larger team members


  • BS in the life sciences field with 3+ years or MS Degree with relevant experience in molecular and cell biology
  • Prior experience in plasmid design, cloning, cell culture, ELISA, western blotting, qPCR, and/or RTPCR.
  • Exceptional communication and presentation skills

  • Prior experience in rare disease, flow cytometry, NGS, animal models.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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