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Scientist, Translational Gene Therapy AAV (non-PhD)

Cambridge, Massachusetts
Closing date
Feb 1, 2022

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Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
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What You Will Achieve

Pfizer's Rare Disease Research Unit (RDRU) focuses on developing drugs for treating rare diseases. The Gene Therapy Translational Research group is part of the RDRU focused on gene transfer approaches to treat rare genetically defined diseases that focus on the CNS, neuromuscular, and liver (systemic and metabolic) therapeutic areas. The Scientist will work as part of a team to explore Pfizer's RNA based approaches to treat rare diseases. The role requires knowledge and expertise in designing and evaluating in vitro and in vivo screens of RNA targets, next generation sequencing and data analysis. The Scientist will perform cell-based and biochemical assays while developing in vivo disease models. The role requires collaboration with cross-functional teams to advance the portfolio programs. Knowledge of human disease and experience with RNA editing is a must.

How You Will Achieve It
  • Evaluate RNA based disease targets
  • Design and execute in vitro and vivo studies utilizing RNA therapeutic modalities
  • Guide RNA design, in vitro and in vivo target assessment, NGS data analysis
  • Perform various biochemical, cell biology, molecular biology, and immunology assays
  • Partner with colleagues in other partner lines


  • B.S. in the life sciences field with 6+ years or M.S. with 4+ years of relevant experience in the field of RNA therapeutics and lipid nanoparticles
  • Prior experience in gene editing technologies and next generation sequencing
  • Evidence of extensive scientific accomplishments in the form of publications and presentations.
  • Evidence of experience working in cross-disciplinary teams.
  • Exceptional communication and presentation skills and demonstrated ability to work independently as well as part of a team.

  • Prior experience in rare disease utilizing small and large animal models

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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