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Senior Principal Scientist, Process Chemistry

Boulder, Colorado
Closing date
Feb 1, 2022

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We are seeking an experienced Process Chemist to join our Chemical Research and Development (CRD) Team in Boulder, CO. CRD, as part of Worldwide R&D and Medical in Pharmaceutical Sciences, is responsible for the development of process technology for the production of active pharmaceutical ingredients (API). This role interfaces with Medicinal Chemistry in Boulder to rapidly develop chemistry to support candidate selection and early clinical studies.

The role requires both direct lab work as well as technical oversight and supervision of 2-3 process chemists. Training members of the new lab around Science of Scale is an essential responsibility, in particular around developing scalable processes which are safe, efficient and robust, use of the state-of-the-art equipment, and the use of computational and predictive tools. Excellent communication skills are required to ensure connectivity with both local Medicinal Chemistry colleagues and the broader CRD group, as is the ability to work on multi-disciplinary teams.

The successful candidate will design, enable and develop scalable processes for the production of active pharmaceutical ingredients (API) for early development programs, applying innovative chemistries, new technologies and statistical experimental design approaches. The ability to work on and lead multi-disciplinary teams involving chemists, analysts, engineers, and technologists, and to represent CRD on cross-functional teams is essential. Partnership with remote manufacturing specialists for API synthesis in the Kilo Lab is required, as well as providing support for technology transfer to third party facilities, including the preparation of technical transfer documents.

  • Interface with Medicinal Chemistry to rapidly develop chemistry to support candidate selection and early clinical studies.
  • Individual lab work focused on early development oncology candidates with a focus on enabling and developing scalable processes, use of the state-of-the art equipment, and the use of analytical, computational and predictive tools.
  • Supervision, including oversight and training, of 2-3 colleagues initially and potentially additional scientific staff in the future.
  • Strong oral communication skills including remote interactions with supervisor and other CRD colleagues in Groton/La Jolla/Sandwich as well as interactions with other Boulder colleagues, in particular Medicinal Chemistry.
  • Excellent written communication skills, including the ability to maintain an accurate scientific notebook, and draft concise written reports, publications, and related documents.
  • Leadership on API project teams in prePOC arena with the ability to work in multi-disciplinary teams involving analysts, process safety scientists, engineers, and technologists as an essential skill.
  • Partnering with remote manufacturing specialists for API synthesis in the Kilo Lab, as well as providing support for technology transfer to CMOs, including the preparation of technical transfer documents.
  • Compliance on safety and regulatory requirements.
  • Travel is occasionally required in support of manufacture (Groton, CT Kilo Lab) and to engage with the broader CRD team, and to participate in scientific conferences.
  • Participation in or leading of key initiatives for CRD and contributing to continuous improvement work in the department and advancement of the Process Chemistry discipline through technology, workflow or business impact.

  • Bachelor's Degree in chemistry and 20+ years' experience in Chemical Research and Development or MS degree in Organic Chemistry with 12-15 years' experience in Chemical Research and Development or PhD in Organic Chemistry and 7-12 years' experience in Chemical Research and Development.

  • PhD. in Organic Chemistry, with 7-12 years of pharmaceutical R&D experience in Process Chemistry.
  • State of the art knowledge of modern synthetic methodology, including aspects of asymmetric synthesis, green chemistry, catalysis and physical organic chemistry as it relates to reaction mechanism is expected.
  • Ability to employ analytical tools and automated laboratory technologies to enhance process development efficiency is desirable.
  • Excellent written and oral communication skills, the ability to effectively influence the work of others, and a general knowledge of drug development and the pharmaceutical industry are key.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.


Laboratory work requiring standing and working at a computer.


Travel is required on occasion to Groton, CT in support of internal technology transfer to Kilo Lab or internal face-to-face meetings, or to participate in scientific conferences.

  • Relocation support available
  • Eligible for employee referral bonus

For roles based in Colorado:

The annual base salary for this position ranges from $106,300 to $177,100 . In addition, this position offers an annual bonus with a target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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