Site Name: USA - Maryland - Rockville Posted Date: Dec 15 2021 Are you a brilliant scientist? Do you want to join a world-leading Research & Development Vaccines environment, and help build its future? This is an exciting opportunity to channel your passion for science to help shape the future of the Vaccines function and revolutionize the way in which GSK conducts its R&D in the future. Do you want to be part of a company investing in scientific and technical excellence to develop a pipeline of new products to meet the needs of patients across the world? About Vaccines R&D As vaccine development has advanced, new types of vaccines have arisen, presenting challenges in characterization and further linking characteristics to function. However, recent development of vaccines against current pandemics or more complex diseases such as influenza has met difficulties. In addition, the gaps in our knowledge on protective responses against pathogens are a significant barrier to ideal vaccine design and are often associated with increased risk of clinical failure. What is Vaccines Scientific Leaders Program? The Scientific Leaders Program in Vaccines is a 2-year global program which builds a pipeline of scientists with the right expertise, technical capabilities and behaviors to drive the future in Vaccines R&D. How does the Vaccines Scientific Leaders Program work? You will spend two years working on a key development project, contributing to key strategic areas of our Vaccines R&D business. Working on challenging projects will provide you with in-depth knowledge of the ways in which Science and Technology is being applied across R&D in GSK. All associates will be contributing to our mission to improve the quality of human life, by enabling people to do more, feel better and live longer - all while fostering strong foundations for a future career in science. Is the Vaccines Scientific Leaders Program for you? This is a scientific/technical leadership position where you will be empowered to be innovative, collaborative, decisive and bold to solve novel R&D problems. On completion of the 2-year program we aim to bring you on-board into available technical leadership roles that best suits business' needs and your abilities. We need Scientific Leaders to help embed modern scientific principles and ways of working within the vaccines R&D organization. You will do this through: Project Title: Cryo-EM polyclonal epitope mapping Project proposal: Establish an advanced pipeline for Cryo-EM polyclonal epitope mapping (EMPEM). Responsibilities: Preparation of samples for Cryo-EM including protein purification, antibody-antigen complex formation, and grid preparation. Independently collect Cryo-EM data on a Glacios or Titan Krios. Provide 2D and 3D analysis of polyclonal antibody-antigen complexes in support of vaccine projects. Possesses strong scientific leadership to enable collaboration with key scientific internal and external stakeholders. Provide detailed scientific analysis of vaccine candidates to cross-functional project teams and key internal stakeholders. High-quality written documentation/presentation of work to enable publications of data in peer reviewed journals, patent filings, etc. To be successful in this role you should have: PhD degree in structural biology, vaccinology, or related field Expertise in all aspects of Cryo-EM sample preparation, data collection, and image processing. Expertise in a variety of Cryo-EM and structural analysis software (i.e Relion, cisTEM, cryoSPARC, PHENIX, Coot, EMAN2). Experience with programming languages such as Python as well as fluency in a Linux environment and High-Performance Computing clusters. Demonstrate willingness to spend ~70% of time on project facing activities (laboratory experiments, computational analysis). Demonstrated ability to conceive and perform independent innovative research. Be a self-starter able to handle multiple projects concurrently. Ability to efficiently manage uncertainty, changes in priorities and timelines. Good knowledge and understanding of GSK Vaccines strategy and objectives, regulatory requirements, as well as competition intelligence and intellectual property aspects. Ability to integrate this knowledge in decisions and recommendations. Excellent communication skills, good team-player, and ability to effectively collaborate within multiple project work streams. Strong track-record of scientific publications in peer-reviewed journals, with at least 2 first author research manuscripts. Experience with Cryo-EM structures of antibody-antigen complexes and with focused classification/refinement (2D and 3D) would be a plus Location: Rockville, MD, US Apply now! We recommend you apply as soon as possible, because we accept ongoing applications and will close this vacancy once we have enough applications. #SLP *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. 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