Site Name: USA - Pennsylvania - Upper Providence Posted Date: Dec 16 2021 We are seeking a highly motivated Scientific Investigator to work on new treatments addressing the threat of infectious diseases by joining our growing Infectious Diseases Research Unit (RU) at Upper Providence, PA. Our team focuses on the unmet medical need for patients with HBV. This experienced scientist will drive projects for antiviral and immunological approaches towards disease remediation with focus on small molecule and/or biologics-based therapeutics. Projects may span from target discovery to candidate selection and early clinical development, along with nonclinical biology work for Phase 2 program for Hepatitis B virus (HBV). The successful candidate will be science driven, familiar with most cell and molecular biology techniques and instrumentation, personally accountable, and eager to learn through experience to advance their career. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following… Independently execute laboratory experiments, conduct statistically supported data analysis, and deliver results in a timely manner to enable informed decision making Conduct pharmacological studies characterizing effects with an array of in vitro techniques that may include immunoassays (ELISA, MSD), qPCR, high-content cell imaging, among others Define, design, and perform experiments using in vitro cellular models to evaluate molecules and or genetic modifiers (e.g., CRISPR, siRNA) to validate drug discovery targets and/or progress lead optimization projects Contribute independently to the direction of the work, providing clear next steps for the research Clearly communicate study results and impact in written form and at internal and external meetings. Commit to continual improvement by reading and applying the latest scientific literature, methodologies and technologies. Comply with all standards and practices of data integrity, ethics, and safety. Model GSKs values of patient-focus, respect, transparency, and integrity Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Master of Science degree with 6-8+ years of relevant research experience (Virology or Immunology) or a PhD with experience in infectious disease area Prior experience working with primary cell cultures and technical experience with cellular/molecular biology and immunology assays (e.g. qRT-PCR, PCR, ELISA or MSD, RNA/DNA transfection, immunofluorescence, flow cytometry, nucleic acid isolation) and with handling of infectious agents. Preferred Qualifications: If you have the following characteristics, it would be a plus: PhD with >2 year post-doctoral experience in infectious disease, preference for HBV or chronic viral infections Understanding of drug discovery via previous experience in biotech/pharmaceutical projects Previous experience in virus infection models and familiarity with the virus/host interaction landscape and immunology Experience with single-cell RNA sequencing and interpretting large data sets Knowledge and experience in immunological assays to probe disease relevant mechanisms In vivo experience with mice for infection studies a plus Demonstrated productivity and impact through laboratory contributions to multiple projects Ability to adapt to changing priorities Strong work ethic with desire to carry out independent hypothesis generation and testing The candidate must be a highly motivated self-starter, with excellent verbal and written communication skills, and the ability to work effectively individually and in team and matrix environments Self-motivated and able to resolve technical challenges and deliver consistent results efficiently in a timely manner Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together. *LI-GSK *This is a job description to aide in the job posting, but does not include all job evaluation details. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.