Bioinformatics specialists

Bioinformatics positions to study systems immunology of infection and vaccination in humans

Summary

We are seeking talented and motivated bioinformatics specialists for Research Scientist positions at 100% FTE for a 3 year fixed term (possibility for renewal). The successful candidates will have expertise in bioinformatics/systems biology with a focus on analyzing omics data, including gene expression profiling, and will work in Dr. Bali Pulendran’s, laboratory at the Institute for Immunity, Transplantation, and Infection at Stanford University. The individuals will join a dynamic, interdisciplinary group of researchers including immunologists, vaccinologists, clinicians, and bioinformaticians, to address major global health issues relating to vaccines and infectious diseases, funded by the National Institutes of Health and the Bill and Melinda Gates Foundation. The successful applicants will perform integrative analysis of omics profiling of the transcriptome, epigenome, and metabolome to discover biomarkers of vaccine efficacy and new biological insights about the human immune system.

Responsibilities

The successful candidates will both lead and collaborate on projects aimed to using systems biological approaches to define the correlates and mechanisms of immunity to vaccination.

• Analyze and integrate omics datasets from multiple platforms (single cell RNA sequencing, single cell ATAC-sequencing, multidimensional flow cytometry and metabolomics).
• Work with a multi-disciplinary team of immunologists, clinicians and bioinformaticians to apply novel and complex statistical approaches to immunological data generated in clinical studies.
• Contribute to the development of bioinformatics workflows and pipelines.
• Collaborate with experimental immunologists in the analysis and visualization of omics data.
• Maintain a database of omics data generated in the lab.

Requirements

The qualified applicants will have:

• A Ph.D. in bioinformatics, computational biology, computer science, or in a relevant biological discipline.
• Demonstrated experience in bioinformatics research, focusing on transcriptional profiling and predictive modeling.
• Familiarity with working in a Linux/Unix environment; experience is Linux system administration and hardware configuration is a plus
• Experience with development and maintenance of relational databases
• Fluency in at least one programming language (R, Python, Perl, Matlab)
• Adequate knowledge of molecular biology, and intention to deepen and improve his/her understanding of these fields. Knowledge in immunology is preferred though not essential.
• Expert knowledge of bioinformatics applications and biological databases
• Strong quantitative or statistical background, experience in machine learning and predictive modeling are highly desirable.

• Excellent verbal and written communication skills.

Excellent opportunities and competitive salaries, and the opportunity to work at the cutting edge of human immunology in a stimulating, diverse and exciting research environment is offered.

How to apply

To apply please send a single PDF file containing your cover letter, CV and the names of three professional referees, quoting “Systems Immunology Positions” in the subject line to Dr. Bali Pulendran at: bpulend@stanford.edu

Website: https://profiles.stanford.edu/bali-pulendran