Site Name: USA - Massachusetts - Cambridge Posted Date: Jan 11 2022 GlaxoSmithKline (GSK) is committed to developing medicines for global health challenges including respiratory, immuno-inflammation, oncology and infectious diseases. We know that finding cures means not just finding new drugs but finding new ways to discover drugs. The Immunology Research Unit identifies and develops novel therapeutic targets for patients with unmet medical need, through leveraging strong genetic datasets, building drug hypotheses from output of functional genomic CRISPR editing screens and performing hands-on experimentation using a wide range of molecular and cellular techniques suitable for drug target identification and validation. Our Genomic Immunology group strives to explore that rich data landscape to derive crucial insight, and to integrate directly with our groundbreaking experimental science. This approach maximizes the probability of delivering successful clinical candidates, and ultimately helping people to do more, feel better and live longer. Description: The Investigator position will reside in the Genomic Immunology Group within the Immunology Research Unit and will be based in Cambridge, MA. The role will allow a highly motivated and skilled candidate to participate in target identification and validation efforts and to take part in the development of novel therapeutics for the treatment of immune disorders with high unmet medical need. This individual will work independently and/or in partnership with cross-functional project dynamic teams in a multidisciplinary matrixed environment to evaluate and propose novel immune targets, investigate their biology of using functional molecular genomic tools, to design novel functional genomic screens and to make significant and high-impact contributions in multiple GSK drug discovery programs. Responsibilities: Identify and validate discovery targets using human genetics, single cell transcriptomics, cellular assays and/or inflammatory disease models Design and perform molecular and cellular assays suitable for drug target identification and validation. Generate, analyze, interpret, present experimental results at various meetings to partners/collaborators and collaboratively plan experimental paths forward Lead and/or support project teams in collaboration with scientists from multiple functional areas Generate study reports and maintain a detailed record of experiments in electronic lab notebooks in accordance with company policy. Publish and present at national/international conferences Share in responsibilities to support general lab functions Why you? Basic Qualifications: PhD in Immunology, or related fields Postdoctoral training preferred but not required Preferred Qualifications: PhD with strong knowledge and research experience in the field of immunology and auto-immune diseases, such as (but not limited to) inflammatory bowel disease, asthma, COPD, multiple sclerosis or atopic dermatitis etc… Technical expertise in CRISPR, siRNA, multi-color flow cytometry, or mouse inflammatory disease models Demonstrated track record of independent critical thinking and scientific achievement in research, exemplified by a strong publication record and/or significant contributions to a therapeutic development program Strong verbal, written communication skills as well as interpersonal skills Knowledgeable, highly motivated, creative, and collaborative Learning agility and drive to continuously improve and develop Previous drug discovery experience in a biopharmaceutical setting Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together. *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. 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