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Research Scientist

Spark Therapeutics
Philadelphia, Pennsylvania
Salary not provided
Closing date
Feb 26, 2022

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Health Sciences, Drug Development
Job Type
Research Scientist
Organization Type
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Job Details

The Research Scientist is a key member of the Pre-clinical Immunology Group within the Research Department.

He/she will be responsible for:

• Planning, executing, and analyzing studies to support Immunology pipeline

• Performing in vitro and in vivo experiments (Hard core bench)

• Propose strategies and design of proof-of-concept studies focused on immunomodulation combined with gene therapy.

• Writing study reports, manuscripts, and presenting results at appropriate scientific meetings.


  • Perform experiments described above and provide training to other team members
  • Design experiments, organize, discuss, and record experimental data
  • Generate technical reports, prepare presentation slides, generate novel concepts Training, lab meetings and administration work
Education and Experience Requirements

• Typically has a PhD in a scientific discipline and 1-2 years of related experience (preferably hands-on research experience with immunological models/assays

• May also have a Bachelor’s or Master’s degree and significant related experience- generally 8+ years. Individual experience may vary based on skillset and expertise.

Key Skills, Abilities, and Competencies

• In-depth knowledge of immunology supported by publication record is required, and previous experience with AAV is a plus.

• Hands-on experience in utilizing genetic engineering or gene-editing approaches

• Prior experience in working with syngeneic mouse models

• Proficiency in isolating and studying immune cells from human and mouse blood

• Experience with in vitro immunological assays such as Elispot, Flow cytometry etc.

• Strong analytical skills and problem-solving capabilities

• Proven ability to work independently in hands-on laboratory setting, self-motivated to learn and develop new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies.

• Excellent communication (oral and written) skills

Complexity and Problem Solving

• Works on complex problems of diverse scope

• Demonstrates good judgment in selecting methods/techniques for obtaining solutions

• Work is performed under minimal direction

• Participates in determining objectives of assignments

• Plans, schedules, and arranges own activities in accomplishing objectives

• Complete understanding and application of principles, concepts, practices, standards

• Responsible and detail-oriented working practice is needed. Ability to prioritize work stream to meet complex deadlines for multiple simultaneous projects

Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.

Nearest Major Market: Philadelphia

Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.


At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
3737 Market Street
Suite 1300
United States
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