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Senior Associate Scientist, In Vivo Pharmacology

Cambridge, Massachusetts
Closing date
Jan 24, 2022

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Life Sciences, Pharmacology, Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Senior Associate Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. The Internal Medicine Research Unit (IMRU) is committed to finding cures for metabolic diseases including Cachexia, Nonalcoholic Steatohepatitis (NASH), Obesity, Diabetes, Renal disease and Heart failure. Our goal is to build a research team of driven scientists focused on identifying and developing novel therapies to improve metabolic homeostasis in patients afflicted with these diseases. The aim is to recruit a scientifically and technically strong research scientist proficient in in vivo to support preclinical studies for drug discovery projects and new target validation. This Senior Associate Scientist will join a biology team within IMRU and contribute to in vivo studies to assess efficacy of novel therapy candidates as well as validate new drug targets. The successful candidate is expected to design and execute in vivo experiments in rodent models. A desire to understand the underlying causes of metabolic diseases and basic metabolic pathways involved is essential and we look for a driven scientist motivated to have a deep understanding of the development of the diseases. It is your hard work and focus that will make Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

  • Design and execute in vivo experiments to address key mechanistic and pharmacological scientific questions.
  • Quantify/translate experimental results, communicate/ present data and provide recommendations for next steps.
  • Working effectively with peers to support projects and workgroup goals.
  • Candidate is expected to maintain high-quality, detailed experimental records within the electronic laboratory notebook.
  • Stay current on all departmental and corporate training.


  • Bachelors of Science with a minimum of 3+ years or a thesis based Master's Degree with 0-3 years work experience in biology, pharmacology, biochemistry, molecular biology , or a related field.
  • Well established hands-on experience with rodent in vivo dosing and handling techniques
  • Experience in tissue dissection and tissue preparation for histology, RNA, and protein analysis
  • Experience in molecular biology techniques such as immunoassays (e.g. ELISA) and western blotting, and quantitative real-time PCR
  • Ability to use appropriate software to perform analysis of data
  • Candidate is expected to be highly detail-oriented, with excellent verbal and written communication skills.
  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, strong motivation with a dedicated work ethic.
  • Strong attention to detail and ability to collaborate and work in team environment.


  • Drug discovery experience
  • Experience in working with tumor models and models of metabolic diseases
  • Experience in standard mammalian cell culture
  • The successful candidate will be an enthusiastic and quick learner who is able to multitask and be comfortable working in a team environment

  • Must be able to wear standard PPE (lab coat/safety shoes/glasses/etc).
  • Must not have animal allergies

  • Eligible for Employee Referral Bonus

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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