A postdoctoral fellowship position in cancer immunotherapy is available at the Center for Advanced Innate Cell Therapy within the Texas Children's Cancer Center. This researcher will be part of an interdisciplinary team of laboratory and clinical investigators developing novel forms of cancer immunotherapy. We offer outstanding state-of-the-art, recently expanded laboratory facilities, a highly interactive team work environment and an individualized approach to career development. The fellow will test human Natural Killer T cells (NKTs) engineered to express tumor-specific Chimeric antigen receptors or T cell receptors for anti-tumor potency using in vitro and in vivo experimental model. In addition, the experiments will focus on dissecting the mechanisms how reprogramming NKTs with specific transcription factors can enhance their antitumor properties. The project is expected to lead to high impact publications in scientific journals as well as the initiation of a phase 1 clinical trial of NKT cells in cancer patients. Candidates must have a PhD degree and an expertise in tumor immunology with a documented record of productivity.Job Duties
- Processes peripheral blood, isolates mononuclear cells and specific cell subsets.
- Performs magnetic cell sorting.
- Performs of numeric expansion of lymphocytes in culture.
- Perform molecular cloning of transgenic T cell receptors.
- Performs retroviral transduction of cultured cells.
- Performs immunoflourescent staining and runs and runs flow cytometry analysis.
- Analyses flow cytometry data using FlowJo and DIVA software.
- Measures cell-mediated cytotoxicity and cytokine production.
- Performs therapeutic experiments in mice.
- Documents results of experiments and prepare reports.
- Writes scientific manuscripts.
- MD or Ph.D. in Basic Science, Health Science, or a related field.
- No experience required.
- An expertise in tumor immunology as documented by at least one first-author publication in a peer-reviewed scientific journal.
Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
PD; CA; SN