Site Name: USA - Pennsylvania - Upper Providence Posted Date: Dec 6 2021 GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent & technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better, & live longer. The primary focus of the role is to support the directed evolution platform by participating in the design, construction, and expression of enzyme libraries. The successful candidate would participate on an interdisciplinary team tasked with providing fit for purpose enzymes to chemistry project teams. As an NGS Assay Specialist (Associate Scientist) you will be responsible for daily lab activities encompassing NGS library preparation and building NGS assays. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include the following: Support enzyme evolution campaigns through the development of sequencing protocols and the execution of those protocols on libraries of enzyme variants Utilize a LIMS system to track samples and analyze NGS output data Interact with bioinformatic colleagues to support NGS sequencing data pipelines Learn new technologies to improve sequencing throughput, cost, and reliability with an aim of streamlining and simplifying sequence acquisition for directed evolution campaigns Collaborate with team to provide project level guidance of best practices and strategic options during evolution campaigns, assay development, and broader platform modifications Maintaining electronic lab notebook records of all experiment work Generate conclusion reports, present data in team meetings & participate in writing of abstracts & publications Work through problems logically and apply innovative solutions (appropriate to grade) Use scientific literature and database resources in the execution of project related work Maintain customer focus, motivate self, and demonstrate a high degree of urgency Exhibit flexibility, being open to new ways of working Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Bachelor's degree and 2-4 years of relevant molecular biology experience Minimum 1 year demonstrated expertise Next-Generation Sequencing (NGS) technology Experience with troubleshooting experiments and assay development workflows Preferred Qualifications: If you have the following characteristics, it would be a plus: Hands-on experience with NGS Library Construction Experience with high-throughput screening Hands- on experience with PCR amplification and size selection methodologies Experience with modern NGS instrumentation Understanding of protein engineering Experience with liquid handling robotics and/or integrated automation platforms Experience in processing and handling large data sets; Linux and/or scripting a major plus Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together. *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. 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