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NGS Assay Scientist

Collegeville, PA
Closing date
Jan 21, 2022

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Physical Sciences, Chemistry
Job Type
Staff Scientist
Organization Type
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Site Name: USA - Pennsylvania - Upper Providence Posted Date: Dec 6 2021 GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent & technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better, & live longer. The primary focus of the role is to support the directed evolution platform by participating in the design, construction, and expression of enzyme libraries. The successful candidate would participate on an interdisciplinary team tasked with providing fit for purpose enzymes to chemistry project teams. As an NGS Assay Specialist (Associate Scientist) you will be responsible for daily lab activities encompassing NGS library preparation and building NGS assays. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include the following: Support enzyme evolution campaigns through the development of sequencing protocols and the execution of those protocols on libraries of enzyme variants Utilize a LIMS system to track samples and analyze NGS output data Interact with bioinformatic colleagues to support NGS sequencing data pipelines Learn new technologies to improve sequencing throughput, cost, and reliability with an aim of streamlining and simplifying sequence acquisition for directed evolution campaigns Collaborate with team to provide project level guidance of best practices and strategic options during evolution campaigns, assay development, and broader platform modifications Maintaining electronic lab notebook records of all experiment work Generate conclusion reports, present data in team meetings & participate in writing of abstracts & publications Work through problems logically and apply innovative solutions (appropriate to grade) Use scientific literature and database resources in the execution of project related work Maintain customer focus, motivate self, and demonstrate a high degree of urgency Exhibit flexibility, being open to new ways of working Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Bachelor's degree and 2-4 years of relevant molecular biology experience Minimum 1 year demonstrated expertise Next-Generation Sequencing (NGS) technology Experience with troubleshooting experiments and assay development workflows Preferred Qualifications: If you have the following characteristics, it would be a plus: Hands-on experience with NGS Library Construction Experience with high-throughput screening Hands- on experience with PCR amplification and size selection methodologies Experience with modern NGS instrumentation Understanding of protein engineering Experience with liquid handling robotics and/or integrated automation platforms Experience in processing and handling large data sets; Linux and/or scripting a major plus Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together. *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
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