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Postdoctoral Fellow - Antibody Engineering for Cancer Therapy

City of Hope
Duarte, California
Closing date
Mar 9, 2022

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Job Details

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope's translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope's specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation's "Best Hospitals" in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope's commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

A Postdoctoral Fellow position is immediately available the department partment of Immunology and Theranostics at the Beckman Research Institute at City of Hope.

Dr. Yazaki's research focuses on the development of novel antibody-based molecules for the imaging and therapy of cancer. The scope includes recombinant antibodies, antibody fragments, fusion proteins, nanoparticles, conjugation chemistry, animal models, PET and NIR fluorescence imaging, radioimmunotherapy, photodynamic therapy, cGMP manufacture and translation into the clinic.

This postdoctoral project offer specialized training in protein design, cloning, expression, purification, biophysical characterization, preclinical animal models, radionuclide/optical imaging and therapy and translation to first-in man clinical studies.

Postdoctoral Fellows are expected to be capable of working rigorously and independently to drive their projects to success. Communication skills (oral and written) are key, and the postdoctoral researcher is expected to present results at professional society conferences and prepare first-author papers each year. City of Hope provide strong support for scientific writing and presentations (abstracts, manuscripts, grant applications and other materials) and offer guidance and opportunities for mentoring (i.e. training graduate students), all in a rich research environment with expertise in antibody engineering, molecular imaging, immunology, and translational sciences for postdocs who want to pursuit a career in academia or industry.

Basic education, experience and skills required for consideration:
  • Ph.D inLife or Biological Sciences and/or related field.
  • Strong background in antibody engineering.
  • Experience in protein design, molecular biology, biochemistry, animal models and/or immunology.

Additional Information:
  • For more information on Dr. Paul Yazaki's research, please visit here: here.
  • As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.




City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research.  City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

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