We are seeking a creative and motivated Postdoctoral Research Fellow to join our collaborative team.
Are you a creative and hardworking individual who wants to do research in an interdisciplinary and fun laboratory setting? The Kim Lab at Wayne State University School of Medicine studies clinically relevant questions in cancer biology using tools from the complementary fields of molecular biology, cell biology, biochemistry and mouse modelling. In particular, our cancer biology work focuses largely to unveil the molecular and cellular mechanisms underlying human cancer progression and to develop better therapeutic strategies. Our laboratory has investigated signaling networks regulated by growth factors, extracellular proteinases, oncogenes and tumor suppressors, critical for tumor progression and therapeutic responses for more than 2 decades. Our research group interacts closely with cancer biologists, clinicians, computational biologists, biochemists and biostatisticians/bioinformaticians.
Current projects focus on understanding genetic alterations in prostate and breast cancer cells for their ability to induce bone reactions necessary for intraosseous tumor growth during bone metastasis. Recent, we identified a novel tumor suppressor that regulate lipid biology, critical for the regulation of tumor cell dormancy in the bone microenvironment. Current projects also include our long-standing research questions on PDGF ligand-specific signaling programs critical for epithelial-stromal interactions. Different PDGF D dimer species generated by extracellular serine proteases induce unique signaling cascades in bone marrow mesenchymal stem cells, distinct from the classic PDGF/PDGFR signaling pathways. The aim of this project is to investigate the molecular mechanisms underlying the novel functions of the PDGF family members in bone formation using in vitro and in vivo animal models as well as clinical specimens.
Our lab also focuses on the interactions of signaling networks with tumor metabolism and programmed cell death pathways. Our novel findings demonstrate that synthetic small molecules targeting tumor cell-specific, lipid metabolic pathways and autophagy induce ferroptotic or apoptotic cell death and improve the effectiveness of radiotherapy in therapy-resistant cancer cells. We aim to investigate the underlying molecular mechanisms and validate new therapeutic targets in treatment-resistant cancers.
Specific responsibilities include:
- Designing and executing in vitro and in vivo experiments
- Conducting data analysis and interpreting results
- Maintaining accurate records, writing reports, and preparing and giving presentations
- Contributing to the overall laboratory safety, organization, and productivity
- Ph.D in molecular biology, cancer biology, genetics, biochemistry or equivalent.
- Must have earned Ph.D. from US institute within 2 years or from foreign institute within 1 year.
- Enthusiastic team player, and self-motivated individual
- Experience with cell culture and experience (or interest) in mouse disease modeling
- Excellent English written and oral communication
About Wayne State University:
Wayne State University is one of the nation's pre-eminent public research universities in an urban setting and Karmanos Cancer Center is one of 51 National Cancer Institute-designated comprehensive cancer treatment and research centers in the United States. Through our multidisciplinary approach to research and education, and ongoing collaboration with government, industry and other institutions including our University Research Corridor partners – the University of Michigan and Michigan State University – Wayne State University - - and our research and technology park, TechTown, seek to expand knowledge, enhance economic growth and improve the quality of life in the city of Detroit, state of Michigan and throughout the world.
Through our dedication and leadership, Wayne State University is a nationally recognized center of excellence in research. Our faculty lead the nation in many key research areas and their groundbreaking discoveries make a difference in the everyday lives of others around the corner and around the world, and we strive to continue making an impact by our groundbreaking research.
Wayne State University and the Karmanos Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.