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Postdoctoral Research Fellowship in Inflammatory Bowel Disease: Harvard Medical School

Employer
Harvard Medical School - Chaikof Lab
Location
Boston, Massachusetts (US)
Salary
NIH Postdoctoral Salary Scale
Closing date
Mar 4, 2022

View more

Discipline
Life Sciences, Immunology, Molecular Biology
Position Type
Full Time
Job Type
Postdoc Fellowship
Organization Type
Academia
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Postdoctoral Research Fellowship in Inflammatory Bowel Disease: Harvard Medical School 

Postdoctoral research fellowship to study the role of the immune system and epithelial repair in inflammatory bowel disease (IBD). The candidate is expected to closely interact with an interdisciplinary team of GI pathologists, biomedical engineers, and medicinal chemists to support a drug discovery program. The project will focus on the evaluation of modulators of mucosal immunity and intestinal epithelial repair processes using animal models of colitis, gut barrier injury, and gut organoid assay systems (see Science Advances 2020; 6:eaay8230). PhD in molecular or cell biology, immunology or related discipline required. Submit CV and the names of three references to echaikof@bidmc.harvard.edu.

Responsibilities

  • Integrate knowledge from molecular and cell biology and immunology to determine the contributions of gut barrier dysfunction in inflammatory bowel disease.
  • Initiate and direct experiments that utilize murine models of colitis and other models of gut barrier injury.
  • Apply a variety of in vitro tools, including intestinal organoid assays and conduct molecular and cellular bioassays, flow cytometry, as well as immunohistochemical studies to characterize the mechanism of action of lead compounds.

Requirements

  • Requires a PhD in molecular or cell biology, immunology or related discipline.
  • Collaborate with members of a multidisciplinary team to efficiently pursue novel strategies that support the discovery of immune modulators for tissue repair and regeneration. 
  • Experience in cell and molecular biology, flow cytometry, other complex bioassays, as well as in vivo studies using mouse models. 
  • Must be an energetic, out-of-box thinker with positive attitude. Excellent written and oral communication skills are required, as is the desire and ability to work in a multidisciplinary environment.
  • Expert knowledge of scientific principles and concepts. Demonstrated success as exemplified by peer-reviewed publications, scientific creativity, and independent thought.   

Project Collaborator: Omer Yilmaz, MD, PhD (MIT)

Interested candidates should contact:

Elliot L. Chaikof, MD, PhD, Johnson and Johnson Professor of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, echaikof@bidmc.harvard.edu

Harvard-MIT Division of Health Sciences and Technology (hst.mit.edu/faculty-research/faculty/chaikof-elliot)

Wyss Institute for Biologically Inspired Engineering (wyss.harvard.edu/team/associate-faculty/elliot-chaikof)

Harvard Stem Cell Institute (hsci.harvard.edu/people/elliot-chaikof-md-phd)

Longwood Harvard Digestive Diseases Center (HDCC)

The Chaikof lab is located in the Center for Life Sciences Building in the Longwood medical area, directly adjacent to Harvard Medical School. CLS 11090, 3 Blackfan Circle, Boston, MA 02115.

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