The Section on Physical Biochemistry (SPB), Division of Intramural Research (DIR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH) in Bethesda, Maryland is recruiting a Postdoctoral Fellow with a background in cell biology, biochemistry or molecular biology. The SPB conducts basic and translational research of bone and extracellular matrix disorders. The DIR of NICHD seeks fundamental knowledge about the nature and behavior of living systems through basic, clinical, and population-based research. The DIR uses this knowledge to illuminate developmental origins of health and disease and to help ensure that women and men have good reproductive health, that children are born healthy, and that people develop to live productive lives. More detailed information about the NICHD DIR may be found at https://www.nichd.nih.gov/about/org/dir/Pages/index.aspx
The Postdoctoral Fellow will investigate molecular mechanisms of bone and lung pathology in osteogenesis imperfecta (OI) and related skeletal disorders, focusing on intracellular trafficking and degradation of the mutant molecules. Our lab discovered that folding, quality control and intracellular trafficking of type I procollagen is drastically different from most other secretory proteins. Misfolding of procollagen triple helix, which is responsible for over 80% of severe OI cases, is not detected by luminal chaperones in the Endoplasmic Reticulum (ER), resulting in noncanonical cell stress response. In particular, our recent multimodal transcriptomic analysis revealed upregulation of Atf5 and Hspa9 in osteoblasts instead of their Atf4 and Hspa5 paralogs that transduce the canonical unfolded protein response. However, the underlying molecular mechanisms remain unknown. The Postdoctoral Fellow will examine molecular pathways involved in this stress response and how misfolded procollagen activates it using cell culture and mouse models. Our group addresses these questions using multidisciplinary approaches, including biochemistry, biophysics, genetics, molecular and cellular biology, single cell and in situ RNA sequencing, and super resolution imaging of live cells. The lab is located in the Clinical Center, a highly interactive research environment within the main NIH campus.
For more information, please see Cell Mol Life Sci 2021, https://doi.org/10.1007/s00018-021-04017-z; The Collagen Superfamily and Collagenopathies 2021, Springer, Chapter 2, Matrix Biol 2020, 93:79-94; PNAS 2018, 115:E10099-E10108; JBMR 2016, 31:1608-1616.
Skills and Qualifications:
- Applicants must have a Ph.D. or M.D. degree (or anticipate receiving their degree in the near future) with less than five years of postdoctoral experience.
- A background in cell biology, biochemistry or molecular biology is required.
- The ideal candidates will have a solid publication record, demonstrating scientific rigor and creativity.
Salary is commensurate with education and experience. US citizenship or permanent residency is not required.
All federal employees must be fully vaccinated against COVID-19. A official job offer is contingent on this requirement. For more information on this requirement, visit the Safer Federal Workforce page on vaccines. If you need a COVID-19 vaccine, please visit Vaccines.gov
Applicants need to submit a resume/curriculum vitae and names and addresses of three references. A brief statement of research interests is strongly recommended. Please submit inquiries regarding this position to Dr. Sergey Leikin (firstname.lastname@example.org).
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.
HHS, NIH, and NICHD are Equal Opportunity Employers.