Investigating the role of Polo kinases (Plk4 and Plk1) orchestrating centrosomal organization, cell division, cell signaling, and tumorigenesis using biochemical, cell biological, structural, and cryo-EM approaches
Position Description: A postdoctoral fellowship is available to study the function of mammalian polo-like kinase 4 and 1 (Plk4 and Plk1) that play central roles in regulating various biological events, including centriole duplication, bipolar spindle formation, chromosome segregation, cell division, and proliferation. Studies show that dysregulation of Plk4/Plk1-dependent processes, by mutations in their associated components or HIV accessory proteins, is tightly linked to the development of aneuploidy and cancer. During the past several years, we have been taking biochemical, cell biological, and structural approaches (e.g., super-resolution imaging, single molecule tracking, in vitro reconstitution, X-ray crystallography, and cryo-EM) to delineate the molecular bases governing Plk4/Plk1’s functionality on the centrosomal architecture, the deregulation of which can lead to the development of many human diseases, including cancers, microcephaly, and AIDS. For additional information, please visit https://ccr.cancer.gov/staff-directory/kyung-s-lee.
Fellows who have an expertise in the field of cell biology, X-ray crystallography, or cryo-EM with a keen interest in learning about the organization and function of the centrosome and their relevance to pathophysiological disorders, such as cancer and AIDS, are encouraged to apply. Applicants should have a Ph.D. (or expected to receive a Ph.D.) or M.D. equivalent at the time of joining the lab and have achieved the degree less than 3 years ago.
To apply, please send CV and three names of references to Dr. Kyung Lee (firstname.lastname@example.org). Starts at $59,900 for fellows with 0 yr postdoc training (+ annual raise) and full health insurance
Employer Name: National Cancer Institute, NIH.
Position Location: 9000 Rockville Pike, Bethesda, MD 20892, U. S. A.
- Kim, T.-S., et al., 2019. Molecular architecture of a cylindrical self-assembly at human centrosomes. Nat. Comm. 10: 1151. Featured article (Editors’ Highlights).
- Park, J.-E., et al., 2019. Phase separation of polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis. Nat. Comm. 10: 4959.
- Wei, Z., et al., 2020. Requirement of the Cep57-Cep63 interaction for proper Cep152 recruitment and centriole duplication. Mol. Cell. Biol. 40:e00535. Featured article (Cover art)
- Ahn, J. I., et al., 2020. Phase separation and versatile capacity of pericentriolar scaffold proteins drive the formation of higher-order self-assemblies at human centrosomes. Cell Cycle. Nov 18:1-21.
- Lee, K. S., et al., 2020. A self-assembled cylindrical platform for Plk4-induced centriole biogenesis. Open Biol. 10:200102 (Review). Featured article (Cover art)
Disclaimer: This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.