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Research Associate

Employer
Spark Therapeutics
Location
Philadelphia, Pennsylvania
Salary
Salary not provided
Closing date
Dec 20, 2021

View more

Discipline
Health Sciences, Drug Development
Job Type
Research Scientist
Organization Type
Biotech
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Job Details

CNS Research Associate

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.

We don’t follow footsteps. We create the path.

Primary Duties

Conduct experiments in the areas of neuroscience, neurodegeneration and cell biology

Use molecular biology, and cell culture techniques (human iPSC-derived neurons, primary neurons, cell lines) to execute studies

Provide technical support in developing and running in-vitro assays for early discovery target assessment.

Provide technical support in running ex-vivo pre-clinical experiments to evaluate treatment efficacy and safety.

Participate in key aspects of general lab management and organization (e.g., managing inventories and stocks of samples, reagents, equipment and materials, and support team members with day to day activities).

Responsibilities

Collaborate to perform experiments on the bench in support of the CNS research projects, including new assay development (in-vitro and ex-vivo) and troubleshooting

Data analysis and an extensive literature review

Oversee and/or provide technical support of specialized equipment as needed

Manage CNS research samples and materials

Manage reagents inventories

Education and Experience Requirements

Bachelor’s degree required, Masters in a relevant field preferred (Neuroscience, Molecular Biology, Cell Biology, Gene Therapy).

Minimum of 2years of relevant experience as Lab Assistant or equivalent.

Knowledge of AAV or gene therapy preferred, but not essential.

Adept at conducting routine testing and limited troubleshooting of multiple methods.

Key Skills, Abilities, and Competencies

At least one-year hands on experience performing cell culture and associated techniques (cell line maintenance, DNA/RNA purification, …)

Experience with CNS cell types (neurons, astrocytes) is highly desirable but not required

At least two years hands-on experience in general molecular biology (DNA and RNA isolation, cloning,

sequencing, PCR, RT-PCR, and Q-PCR), protein biochemistry and cell biological approaches.

Able to organize ordering and receiving of lab materials and supplies.

Able to manage samples and perform experiments with some oversight.

Ability to manage competing priorities in a fast-paced environment.

Strong interpersonal skills demonstrated by the ability to lead and gain the assistance and cooperation of others in a team endeavor.

Strong organizational skills and communication skills.

Independently motivated and exceptionally detail oriented.

Ability to learn new techniques and work independently after training

Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.


Nearest Major Market: Philadelphia



Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.

Company

At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
Website:
Telephone
215-989-1149
Location
3737 Market Street
Suite 1300
Philadelphia
PA
19104
United States
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