Site Name: USA - Pennsylvania - Upper Providence Posted Date: Dec 13 2021 Are you energized by a challenging role in biology, where scientific demand is driving team growth? If so, this Senior Scientist role would be a great opportunity to consider. We are seeking a highly motivated Senior Scientist to work on new treatments to address the threat of infectious diseases by joining our growing Infectious Diseases Research Unit (RU) at Upper Providence, PA. The Infectious Diseases Research Unit is one of the 4 Research Units in the R&D organization at GSK and is responsible for the discovery of novel approaches & targets to treat infectious diseases that threaten our health and progressing them to clinical proof of concept studies. The Research Unit has an impactful portfolio of projects in hepatitis B, bacterial infections, and viral respiratory infections (including COVID-19) along with collaborations with Vir Biotechnology and 23&Me. You would be responsible for conducting molecular and cell biology experiments to progress drug discovery projects targeting HBV and other potential viral targets. Particular areas of focus will be in evaluating target or compound in primary human hepatocyte cell culture with HBV or other innovative approaches in the pursuit of a functional cure for HBV. The successful candidate will be science driven, familiar with most cell and molecular biology techniques and instrumentation, one who assumes personal accountability and keen to learn through experience to advance in their career. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following… Design, and perform experiments using in vitro cell culture models to evaluate molecules and or genetic modifiers (e.g., CRISPR, siRNA) to validate drug discovery targets and/or progress lead optimization projects Conduct pharmacological studies characterizing effects with an array of in vitro techniques that may include immunoassays (ELISA, MSD), TaqMan, and high-content cell imaging, among others Independently execute laboratory experiments, conduct statistically supported data analysis, and deliver results in a timely manner to enable informed decision making Clearly communicate study results and impact in written form and at internal and external meetings. Comply with all standards and practices of data integrity, ethics, and safety. Model GSKs values of patient-focus, respect, transparency, and integrity Define, design, and execute experiments Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Master of Science degree (virology, immunology, cell biology or related field) with 3-5+ years of relevant research experience or a Bachelor's degree with 5-7+ years of lab experience. Prior experience working with primary cell cultures and technical experience with cellular/molecular biology and immunology assays (e.g. qRT-PCR, PCR, ELISA, RNA/DNA transfection, immunofluorescence, flow cytometry). Preferred Qualifications: If you have the following characteristics, it would be a plus: Strong work ethic with desire to carry out independent hypothesis generation and testing Highly motivated self-starter, with excellent verbal and written communication skills, and the ability to work effectively both individually and collaboratively in team and matrix environments Previous experience handling patient samples and documenting study details and results in written reports. 2-3+ years pharmaceutical or biotechnology experience working in a matrixed drug discovery project team Previous experience with in vitro viral infection of cell cultures and quantification of viral levels in biological samples. Demonstrated experience: Complex in vitro cell models 3-D cell culture Using high-content imaging to characterize intracellular events Utilizing genetic modifiers (e.g. siRNA) and/ or genomic-scale gene expression and data analysis techniques Experience with liquid handling instruments (e.g. BRAVO or BioMek) Outstanding written and oral communication skills Ability to adapt to changing priorities Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together. *LI-GSK *This is a job description to aide in the job posting, but does not include all job evaluation details. 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