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Senior Principal Computational Biologist

Cambridge, Massachusetts
Closing date
Dec 16, 2021

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Life Sciences, Biology, Computational Biology
Position Type
Full Time
Organization Type
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Pfizer's Rare Disease Research Unit (RDRU) is dedicated to the development of novel therapeutics for orphan diseases. As a member of our Integrative Biology team located in Cambridge, Massachusetts, you will lead efforts to design, execute, and communicate computational analyses combining public and proprietary multi-omics datasets. You will work both independently and in teams with laboratory biologists, computational biologists, geneticists, and statisticians within the RDRU and across the broader Pfizer community in a friendly and highly collaborative environment to deliver impactful and actionable insights. You will be challenged to apply your scientific expertise, critical thinking, and creativity both to advance our existing drug portfolio and to identify novel target opportunities. A successful candidate will also be a highly motivated learner who is looking to grow as a scientist and as a leader.

  • Design, execute, document, and communicate integrative multi-omics data analyses
  • Apply principles of sound statistical design and develop novel methods when appropriate
  • Stay current with relevant biological and computational literature, conference proceedings, and emerging methodologies
  • Manage, develop, and maintain internal and external collaborative projects to specified timelines and milestones
  • Synthesize and clearly communicate study findings and analyses to a diverse audience of internal partners, leadership, and collaborators
  • Manage, support, and promote relationships with the external community that can add value to target selection and validation for the RDRU


Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
  • Background in biological and/or quantitative sciences; PhD in a biology, cellular/molecular biology, computational biology, data sciences, or a related field with 5+ years of relevant experience, preferably in a pharma or biotech environment
  • Sound statistical and quantitative skills with an understanding of the methods implemented by commonly used 'omics data analysis packages
  • Fluency in start-to-end analysis of multiple types of 'omics data such as bulk RNAseq, scRNAseq, spatial transcriptomics, ChIP-seq, proteomics, metabolomics, or epigenetics with particular expertise in at least one these
  • Proficient in programming, scripting, querying and statistical analysis languages such as R, Python, and SQL
  • Proficient in Unix-based command line interface and familiarity with high performance computing
  • Proficient in standard methods for reproducible research such as Jupyter notebooks and/or Rmarkdown
  • Familiar with versioning tools such as git
  • Deep understanding of human biology/medicine, ideally with experience in any one of the following: neurology/neurodegenerative disease, repeat expansion disease, cardiomyopathy, non-oncological hematology, or metabolic disease
  • Excellent communication, interpersonal, and presentation skills
  • Ability to multi-task and prioritize amongst competing time-sensitive projects
  • Prior experience leading group projects
  • Strong desire and demonstrated ability to continually learn new skills

  • Knowledge of Bayesian data analysis methods
  • Track record of innovative and impactful research including peer-reviewed publications
  • Experience coding and deploying data visualization applications such as R Shiny
  • Experience packaging and maintaining reusable code

Other Job Details

Eligible for Relocation Package

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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