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Sr. Principal Scientist, BMD Biotherapeutic Production

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Closing date
Dec 15, 2021

View more

Discipline
Physical Sciences, Chemistry, Other, Manufacturing/QA/QC
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
Pharma
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ROLE SUMMARY

Pfizer's BioMedicine Design (BMD) Biotherapeutic Expression and Purification group (BEP) is seeking a creative and driven senior candidate to lead RNA Therapeutic discovery technologies and RNA production process development. The candidate will capitalize on their experience with mRNA and self-replicating RNA to develop processes for delivery of in-vivo grade RNA therapeutics supporting the RNA-based therapy portfolio across Pfizer and their pre-clinical therapeutic in-vitro and in-vivo needs. The candidate will contribute to department wide deliverables and be required to lead a team of direct reports, work on several projects simultaneously presenting results, and updates at group meetings.

ROLE RESPONSIBILITIES
  • Lead development of RNA therapeutics process optimization and scale-up
  • Oversee and support all aspects of RNA production, IVE and characterization, collaborate on LNP formulation
  • Collaborate with groups across Pfizer to develop processes compatible with and capitalizing on existing internal knowledge/infrastructure
  • Routinely generate top quality data packages and present at project meetings
  • Propose experimental designs and work closely with cross-functional teams, project leads and senior group members on identifying/advancing best strategies and planning/executing deliverables
  • May lead therapeutic discovery projects
  • Mentor and support junior staff and build a culture of support and collaboration
  • Work closely with multidisciplinary teams including therapeutic discovery teams, research units, bioanalytical teams, transient expression and stable cell line development groups, engineering leads, and R&D project leaders


BASIC QUALIFICATIONS
  • PhD in Chemical/Biochemical/Biological Engineering or a related discipline with 6+ years of industry experience with mRNA and self-replicating RNA engineering
  • Significant experience with mammalian expression regulation and engineering
  • Experience in cell culture, cell line maintenance, and various reporter assays (including flow cytometry).
  • Extensive experience with DNA and RNA manipulation (including recombinant DNA techniques, IVT, sequence analysis, DNA/RNA isolation, RT-qPCR/ddPCR, purification and analysis).
  • Curiosity and passion for research with strong interest in synthetic biology and gene therapy, creative and flexible thinking
  • Ability to plan, organize, problem solve (troubleshoot), design experiments, work efficiently independently and in a multidisciplinary team
  • Excellent communication skills, written and oral


PREFERRED QUALIFICATIONS
  • Experience with self-replicating RNA a plus
  • Prior managerial experience preferred


Other Job Details:
  • Last Date to Apply: December 14, 2021
  • Eligible for Employee Referral Bonus
  • Eligible for Relocation


#LI-PFE

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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