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Ocular Research Leader

Spark Therapeutics
Philadelphia, Pennsylvania
Salary not provided
Closing date
Dec 9, 2021

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Health Sciences, Drug Development
Job Type
Research Scientist
Organization Type
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Job Details

Ocular Pre-Clinical Research Leader

The Ocular Pre-Clinical Research Leader will manage one or more Ocular therapeutic programs within the Research function. S/he will be responsible for:

• Directing and overseeing candidate development from early discovery and proof-of-concept through IND enabling studies for specific ocular programs, providing leadership within a group of scientists/research associates.

• Initiation and active oversight of joint programs with external collaborators.

• Establishing and managing project timelines and ensuring work is completed according to schedule.

• Training and developing staff at varying levels of experience.

• Writing and reviewing documents to support regulatory filings, manuscripts, and present results at appropriate scientific meetings.

The Ocular Pre-Clinical Research Leader position supports translational research of gene therapies including:

• Target validation and lead identification/optimization, by using a combination of molecular, cellular and in vitro/in vivo techniques for gene therapy programs.

• Developing strategies to support delivery and transgene expression of our gene therapies in laboratory animals.

• Delivering rigorous, interpretable and scientifically sound IND enabling studies to facilitate product development (e.g. proof-of-concept, dose-ranging, GLP-Tox, biodistribution/vector shedding, etc.)


Lead a team of scientists to develop programs through preclinical development and to clinical stage. Mentor and develop staff.

Develop operational goals and ensure departmental goals and objectives are met and aligned to the broader organizational goals and objectives.

Identify and validate new indication targets. Design and trouble-shoot experiments based on personal experience and literature review. Prepare and deliver scientific presentations at internal and external meetings

Prepare sample analysis reports and write parts of regulatory submissions to regulatory agencies.

Prioritize projects, plan workload, manage resource and personnel scheduling.

Hands-on execution of experiments on the bench.

Education and Experience Requirements

• Ph.D. in a relevant scientific discipline (e.g. cell and molecular biology, biochemistry, etc.)

• 15+ plus years of hands-on experience in the field of gene therapy or a relevant field of expertise.

• Familiarity with IND enabling studies, regulatory filings, and/or GLP studies is required

• Proven expertise in AAV gene therapy and/or in the ocular space.

• Strong publication record is a plus.

• 5+ years of proven success in managing individual and teams

• Experience managing external collaborations is a plus.

Manage team members to achieve business goals and objectives.

• Foster Spark’s Culture. Role model the Spark Values. Create an environment where team members thrive by living our truths, always in compliance with applicable laws and regulations. Emphasize to employees that “how” they achieve performance objectives is just as important as “what” they accomplish.

• Hire & Integrate. Know what skills, experiences and capabilities are needed to achieve current and future business goals. Take an active role in attracting and selecting talent who are inspired by our Mission, Vision and Values. Consciously create a team with diverse backgrounds, experiences, skill sets and perspectives. Help new team members successfully integrate into Spark so they can actively contribute and add value as quickly as possible.

• Manage performance. Ensure every team member knows what is expected of them, what it takes to be successful, and how they are progressing. Provide team members with continuous and on-going performance feedback, holding everyone accountable to achieve results while demonstrating the Spark Values. Help team members understand how their work contributes to the overall success of Spark by continuously communicating priorities, decisions and changes; adjusting goals as needed.

• Develop people. Understand each individual team member’s career goals. strengths and motivators. Partner with your employees to identify areas for development, conduct coaching conversations regularly and provide guidance on ways to develop through on the job experiential learning and stretch opportunities.

Key Skills, Abilities, and Competencies

• Experience with studies in laboratory animals.

• Excellent communication skills (both oral and written).

• Strong analytical skills and problem-solving capabilities.

• Successful leadership and management experience

Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.

Nearest Major Market: Philadelphia

Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.


At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
3737 Market Street
Suite 1300
United States
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