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Research Associate - Ocular

Spark Therapeutics
Philadelphia, Pennsylvania
Salary not provided
Closing date
Jan 12, 2022

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Health Sciences, Drug Development
Job Type
Research Scientist
Organization Type
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Job Details

The Ocular Research group within Spark Therapeutics is seeking a highly motivated Research Associate to support laboratory efforts towards the development and testing of novel gene therapy products.

Primary responsibilities:

• Execute molecular biology and in vitro experiments (e.g., DNA prep, DNA cloning, qPCR, Jess, cell culture)

• Execute tissue preparation for histology and immunohistochemistry staining

• Execute mammalian cell culture and maintaining a cell bank

• Maintain the Ocular plasmid inventory under the direction of senior Ocular team members

• Compile in vivo (fundus, OCT) and histology image summaries

• Participate in sample management activities such as receiving, processing, storage and shipping clinical and preclinical samples.

• Accurately document assay results and analyze data using an electronic lab notebook, technical documents, and other reporting formats.

• Contribute to a collaborative, creative and rigorous culture of scientific discovery


Plan, prepare and perform experiments on the bench to support the Ocular Platform research projects. Assist technical staff in the performance of laboratory experiments as needed.

Analyze results, prepare technical reports, and accurately document work in an electronic lab notebook. Prepare PowerPoint presentations of results as needed. Communicate results and research progress during team meetings as needed.

Participate in group meetings, scientific discussions, and provide support to more junior staff, as needed.

Education and Experience Requirements

• BA/BA in Biological sciences required.

• 0-3 years of laboratory experience.

• Experience in image report generation and analysis.

• Experience in mammalian and bacterial cell culture

• Experience with AAV a plus.

Key Skills, Abilities, and Competencies

• Experience in general laboratory techniques such as molecular cloning, qPCR, ELISA, cell culture, immunohistochemistry, western blotting, etc.

• Ability to work independently in a hands-on laboratory setting after initial training, self-motivated to learn and develop new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies.

• Strong organizational skills.

• Excellent communication skills (both oral and written).

• Works with colleagues as a team player.

• Familiarity with Electronic Lab Notebook (ELN) and Laboratory Information Management Systems (LIMS) is a plus.

Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.

Nearest Major Market: Philadelphia

Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.


At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
3737 Market Street
Suite 1300
United States
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