Investigator, Protein & Cellular Sciences

Site Name: USA - Pennsylvania - Upper Providence Posted Date: Dec 1 2021 Investigator, Genome editing An exciting opportunity has arisen for a highly motivated molecular biologist with a passion for protein technology, to join the department of Protein, Cellular, and Structural Sciences (PCSS) at GSK's facility in Upper Providence, Pennsylvania. The primary responsibility of the department is to design, generate and validate biological reagents for discovery activities across all of GSK's therapeutic modalities. The department also provides the structural and mechanistic understanding of drug target, molecular recognition and mode of action to deliver the best molecule. In this role, the scientist will function in a matrix team to deliver cell reagents to support work packages in multiple therapeutic areas including Oncology, Immunology, Infectious Disease, Neurology and Inflammation. The candidate will possess hands-on experience and a deep knowledge of variety of CRISPR genome editing strategies (KO, KI, base editing, activation/interference, prime editing) and design and analysis tools. Key Responsibilities include, but are not limited to: Independently plan experiments, generate and deliver cell reagents using genome editing to multiple project teams Actively seek out to develop/adopt new technologies/editing strategies to make workflow more efficient Contribute to program strategies and plans in multiple matrix teams to drive drug discovery Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety training and practice Why you? Basic Qualifications: PhD in Genomics, Molecular Biology, Cell Biology, Oncology, Genetics or related fields Extensive hands-on experience in CRISPR genome editing and analysis tools Preferred Qualifications: If you have the following characteristics, it would be a plus: Ability to plan and execute multiple tasks concurrently and evaluate multiple scientific strategies in parallel where appropriate Demonstrated strengths in high performance behaviors, such as building relationships, flexible thinking, and enabling/driving change. Broad understanding in multiple different areas of biological sciences including oncology, immunology, infectious diseases, metabolic diseases and neurology Extensive cell culture including cell lines, primary cells, co-culture/advanced cellular models and iPSC Practical understanding in genetics, target validation, compound screening and assay development Documented experience or publications in technology development in the area of genome editing or related emerging fields Experience in functional genomics tools including sequencing (Sanger and NGS), genotyping, primer/probe design, qRT-PCR, ddPCR and Snapgene/Benchling (or equivalent software) Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. 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