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Early Career Scientist - Computational Biology and/or Bioinformatics

Employer
Tsibris Lab, Brigham and Women's Hospital, Harvard Medical School
Location
Cambridge, Massachusetts
Salary
Commensurate with experience
Closing date
Dec 31, 2021

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Job Details

We seek an outstanding and highly motivated early-career scientist in the fields of computational biology and/or bioinformatics. The position will involve novel integrated multimodal analyses of single cell datasets in blood immune cells and tissue. Qualified candidates will have an opportunity to design research projects that leverage cutting-edge approaches that include paired ATAC-seq and RNA-seq, ASAP-seq, and ECCITE-seq. This postdoctoral fellowship provides a unique opportunity to conduct research with broad scientific and technical impact.

The Tsibris Laboratory studies the biology of HIV latency and its reversal in the context of human disease. The guiding principle of our work is a cure for HIV. The Tsibris lab is located in Cambridge, MA, an area rich in world-class academic centers, pioneering biotechnology and pharmaceutical companies, and a diverse, welcoming, and inclusive community. Fellows will hold the academic rank of Research Fellow at Brigham and Women’s Hospital and Harvard Medical School and be provided a competitive salary and benefits. Appointments are anticipated for two years, with renewal after the first year contingent upon satisfactory performance.

Applicants must hold a PhD degree, or the equivalent, and have significant expertise in bioinformatics and/or computational biology. The ideal candidate will have prior experience in performing integrated single cell bioinformatics analyses and be motivated to apply computational approaches to study the biology of the immune system and retroviral pathogens. Experience in immunology research is preferred. Publications in leading journals and completion of a doctoral degree in a relevant scientific field before the start date are required.

Interested candidates should email a cover letter, detailed curriculum vitae, and research interests as a single PDF to:

Dr. Athe Tsibris

Brigham and Women’s Hospital

Harvard Medical School

65 Landsdowne Street, Room 422

Cambridge, MA 02139

atsibris@bwh.harvard.edu

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

Company

The Tsibris Lab studies the biology and dynamics of HIV reservoirs in blood and tissue. We use these insights to expand our understanding of HIV persistence and design and test novel strategies to eliminate latently HIV-infected cells.

Lentiviral integration into CD4+ T cells, and potentially other cell types, is the major barrier to HIV eradication. Efforts to reactivate virus transcription and clear the reservoir through immune-mediated approaches have identified an important problem: the reversal of HIV latency may not generate sufficient virus antigen to clear the reservoir. Our lab seeks to understand precisely what, mechanistically, is required to reactivate HIV translation while minimizing off-target effects on cell function; virtually any eradication approach based on the human immune system will require HIV translation. We use novel technologies to define the transcription factor requirements of robust latency reversal, quantify HIV translation efficiency, and map the cellular pathways that are essential to virus reactivation. Particular interests include HIV-1 reservoir dynamics in women, HIV-2 latency, the role of RNA structure in latency reversal, and the effects of opioid use on virus reactivation. This work leverages our HIV Eradication and Latency (HEAL) cohort and a network of collaborators in industry and academia to deliver on the promise that the use of the word “cure” implies.

Find Us
Website:
Telephone
6174171162
Location
65 Landsdowne Street Room 422
Cambridge
MA
02139
US
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