Lawrence Berkeley National Lab’s (LBNL) Molecular Biophysics & Integrated Bioimaging Division has an opening for a National Lab and Synchrotron Postdoc for Biology.
In this exciting role, you will integrate into a multi-disciplinary team of scientists to tackle national priorities in pandemic response and climate change through structural biology. The Postdoc will manipulate samples (typically macromolecular complexes or cells) provided by an extensive network of collaborators both external and internal to LBNL and prepare them for synchrotron-based techniques (small angle X-ray scattering, crystallography, X-ray Tomography, and others). The Postdoc will help collect data from samples and connect results to biologically relevant phenomenon. The Postdoc will be involved in planning experiments, sometimes as early as the proposal stages. The Postdoc may interface with viral proteins, antibodies and their derivatives, engineered proteins, metalloproteins, and microbial metabolism regulation proteins and pathways. While centered at the Advanced Light Source (ALS) synchrotron, the Postdoc will develop ties to other LBNL organizations like the Joint BioEnergy Institute (JBEI), Joint Genome Institute (JGI), Molecular Foundry, and National Energy Research Scientific Computing Center (NERSC).
What You Will Do:
Participate with other members of the scientific team in the application of unique LBNL infrastructure to address pandemics and climate change through structural biology. Plan and execute the collection of crystallographic, SAXS and X-ray Tomography on core mission samples. Publish scientific papers in peer-reviewed journals and present findings at seminars and conferences. Participate in development of grant proposals for new research directions and preparation of competing renewals of current research grants. Maintain an accurate and detailed online laboratory notebook of all experiments performed and provide sufficient details to ensure methods and results can be duplicated by others. Collaborate with program projects that utilize synchrotron beamlines for research and develop new collaborations as appropriate to further the scientific goals of the programs (https://sibyls.als.lbl.gov/). Cooperate with other members of the SIBYLS beamline and the Advanced Light Source division.
Additional Responsibilities as needed:
Participate in professional scientific activities (e.g., review of papers, research proposals, etc.). Support and contribute to the development of research project ideas and proposals. Participate in relevant professional societies with relevance to the program and group activities.
What is Required:
PhD in Biology, Chemistry, or Physics. Experience in expression, purification, and handling of biological macromolecules. Computational programming skills in any major programming language.(C, Python, etc.) A passion to solve national priorities in climate and human health. Excellent communication skills and a commitment to team science. Ability to work as a member of a small team where each member fills in gaps in effort and expertise. In-depth understanding of protein, DNA, and RNA structure.
Computational tools in protein engineering. Experience working with antibodies. Experience working with metalloproteins. Experience working on DNA or RNA binding proteins. Start to finish protein production to X-ray crystal structure.
This is a full-time, 2 year, postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. You must have less than 2 years of paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree. This position is represented by a union for collective bargaining purposes. Salary will be predetermined based on postdoctoral step rates. This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment. Work will be primarily performed at Lawrence Berkeley National Lab, 1 Cyclotron Road, Berkeley, CA.
Molecular Biophysics and Integrated Bioimaging
Mission: To generate a mechanistic and predictive understanding of biological processes, by developing and applying molecular- and meso-scale visualization and advanced spectroscopies, enabling the control, manipulation and generation of biological function.
Vision: To generate fundamental knowledge that inspires a mechanistic understanding of biological processes, with the ultimate goal of manipulating, controlling, and creating biological functions in order to solve national challenges in energy, environment, health and biomanufacturing.