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Investigator, Upstream Vector Process Development

Collegeville, PA
Closing date
Dec 7, 2021

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Other, Manufacturing/QA/QC
Job Type
Group Leader/Principal Investigator
Organization Type
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Site Name: USA - Pennsylvania - Upper Providence Posted Date: Sep 16 2021 GSK's Cell & Gene Therapy's Vector Process Development Group is responsible for delivering the Manufacturing Process of Viral Vectors for Cell and Gene Therapy Products. This position will provide the successful candidate an opportunity in a Research and Design (R&D) laboratory to develop upstream and downstream processes needed to manufacture viral vectors. The candidate will design and execute studies using a variety of laboratory techniques such mammalian cell culture (suspension culture), cell banking( MCB, WCB, EOP, PPCB), upstream process development in bioreactors (50L STR, 2L STR, or AMBR operation), design of experiments planning and analysis, assay techniques ( titer determination). The candidate will support the tech transfer of these viral vector processes to internal and external manufacturing sites. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: MS or PhD degree in molecular medicine, molecular biology, chemical engineering, biology, immunology, biotechnology or related majors Demonstrated ability to work in multi-disciplinary, multi-cultural, matrix teams Designs and executes new methods and protocols related to area of expertise and/or proactively incorporates new technology or techniques into practice with minimal supervision. Identifies and troubleshoots problems in the execution of experimental processes/technical studies/tasks. Independently writes specific technical sections of internal and external reports. Anticipates problems and proactively seeks input from other scientists and engineers. Executes experiments and data management activities that result in robust, high quality data to inform R&D decision making. Preferred Qualifications: If you have the following characteristics, it would be a plus: Process development or GMP experience is desirable Scale-up experience with mammalian cell culture (such as familiarity with Satorius single-use bioreactors or AMBR bioreactors) Tech transfer experience Gene therapy, such as lentiviral vector, experience Automation experience Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. *This is a job description to aide in the job posting, but does not include all job evaluation details. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
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